Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities

Prostate cancer is the most common non-cutaneous cancer among American men. Multiple mechanisms are involved in tumorigenesis and progression to metastases. While androgen deprivation therapy remains the cornerstone of treatment, progression to castration-resistant disease becomes inevitable. Aberra...

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Detalles Bibliográficos
Autores principales: Yu, Eun-mi, Hwang, Min Woo, Aragon-Ching, Jeanny B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693764/
https://www.ncbi.nlm.nih.gov/pubmed/38050587
http://dx.doi.org/10.2147/RRU.S386517
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author Yu, Eun-mi
Hwang, Min Woo
Aragon-Ching, Jeanny B
author_facet Yu, Eun-mi
Hwang, Min Woo
Aragon-Ching, Jeanny B
author_sort Yu, Eun-mi
collection PubMed
description Prostate cancer is the most common non-cutaneous cancer among American men. Multiple mechanisms are involved in tumorigenesis and progression to metastases. While androgen deprivation therapy remains the cornerstone of treatment, progression to castration-resistant disease becomes inevitable. Aberrant pathway activations of PI3K/AKT due to PTEN loss, epithelial–mesenchymal transition pathways, homologous recombination repair, and DNA repair pathway mechanisms of resistance and cross-talk lead to opportunities for therapeutic targeting in metastatic castration-resistant prostate cancer. This review focuses on mechanisms of progression and key trials that evaluate the drugs and combinations that exploit these pathways.
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spelling pubmed-106937642023-12-04 Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities Yu, Eun-mi Hwang, Min Woo Aragon-Ching, Jeanny B Res Rep Urol Review Prostate cancer is the most common non-cutaneous cancer among American men. Multiple mechanisms are involved in tumorigenesis and progression to metastases. While androgen deprivation therapy remains the cornerstone of treatment, progression to castration-resistant disease becomes inevitable. Aberrant pathway activations of PI3K/AKT due to PTEN loss, epithelial–mesenchymal transition pathways, homologous recombination repair, and DNA repair pathway mechanisms of resistance and cross-talk lead to opportunities for therapeutic targeting in metastatic castration-resistant prostate cancer. This review focuses on mechanisms of progression and key trials that evaluate the drugs and combinations that exploit these pathways. Dove 2023-11-29 /pmc/articles/PMC10693764/ /pubmed/38050587 http://dx.doi.org/10.2147/RRU.S386517 Text en © 2023 Yu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yu, Eun-mi
Hwang, Min Woo
Aragon-Ching, Jeanny B
Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
title Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
title_full Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
title_fullStr Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
title_full_unstemmed Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
title_short Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities
title_sort mechanistic insights on localized to metastatic prostate cancer transition and therapeutic opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693764/
https://www.ncbi.nlm.nih.gov/pubmed/38050587
http://dx.doi.org/10.2147/RRU.S386517
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