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COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent respiratory symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have demonstrated both higher rates of COPD and an earlier and more r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693779/ https://www.ncbi.nlm.nih.gov/pubmed/38050482 http://dx.doi.org/10.2147/COPD.S388142 |
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author | Byanova, Katerina L Abelman, Rebecca North, Crystal M Christenson, Stephanie A Huang, Laurence |
author_facet | Byanova, Katerina L Abelman, Rebecca North, Crystal M Christenson, Stephanie A Huang, Laurence |
author_sort | Byanova, Katerina L |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent respiratory symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have demonstrated both higher rates of COPD and an earlier and more rapid decline in lung function than their seronegative counterparts, even after accounting for differences in cigarette smoking. Factors contributing to this HIV-associated difference include chronic immune activation and inflammation, accelerated aging, a predilection for pulmonary infections, alterations in the lung microbiome, and the interplay between HIV and inhalational toxins. In this review, we discuss what is known about the epidemiology and pathobiology of COPD among PWH and outline screening, diagnostic, prevention, and treatment strategies. |
format | Online Article Text |
id | pubmed-10693779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-106937792023-12-04 COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies Byanova, Katerina L Abelman, Rebecca North, Crystal M Christenson, Stephanie A Huang, Laurence Int J Chron Obstruct Pulmon Dis Review Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by airflow limitation and persistent respiratory symptoms. People with HIV (PWH) are particularly vulnerable to COPD development; PWH have demonstrated both higher rates of COPD and an earlier and more rapid decline in lung function than their seronegative counterparts, even after accounting for differences in cigarette smoking. Factors contributing to this HIV-associated difference include chronic immune activation and inflammation, accelerated aging, a predilection for pulmonary infections, alterations in the lung microbiome, and the interplay between HIV and inhalational toxins. In this review, we discuss what is known about the epidemiology and pathobiology of COPD among PWH and outline screening, diagnostic, prevention, and treatment strategies. Dove 2023-11-29 /pmc/articles/PMC10693779/ /pubmed/38050482 http://dx.doi.org/10.2147/COPD.S388142 Text en © 2023 Byanova et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Byanova, Katerina L Abelman, Rebecca North, Crystal M Christenson, Stephanie A Huang, Laurence COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies |
title | COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies |
title_full | COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies |
title_fullStr | COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies |
title_full_unstemmed | COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies |
title_short | COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies |
title_sort | copd in people with hiv: epidemiology, pathogenesis, management, and prevention strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693779/ https://www.ncbi.nlm.nih.gov/pubmed/38050482 http://dx.doi.org/10.2147/COPD.S388142 |
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