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Collagen‐Based Hydrogels for Cartilage Regeneration

Cartilage regeneration remains difficult due to a lack of blood vessels. Degradation of the extracellular matrix (ECM) causes cartilage defects, and the ECM provides the natural environment and nutrition for cartilage regeneration. Until now, collagen hydrogels are considered to be excellent materia...

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Autores principales: Sun, Lihui, Xu, Yan, Han, Yu, Cui, Jing, Jing, Zheng, Li, Dongbo, Liu, Jianguo, Xiao, Chunsheng, Li, Dongsong, Cai, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694028/
https://www.ncbi.nlm.nih.gov/pubmed/37942509
http://dx.doi.org/10.1111/os.13884
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author Sun, Lihui
Xu, Yan
Han, Yu
Cui, Jing
Jing, Zheng
Li, Dongbo
Liu, Jianguo
Xiao, Chunsheng
Li, Dongsong
Cai, Bo
author_facet Sun, Lihui
Xu, Yan
Han, Yu
Cui, Jing
Jing, Zheng
Li, Dongbo
Liu, Jianguo
Xiao, Chunsheng
Li, Dongsong
Cai, Bo
author_sort Sun, Lihui
collection PubMed
description Cartilage regeneration remains difficult due to a lack of blood vessels. Degradation of the extracellular matrix (ECM) causes cartilage defects, and the ECM provides the natural environment and nutrition for cartilage regeneration. Until now, collagen hydrogels are considered to be excellent material for cartilage regeneration due to the similar structure to ECM and good biocompatibility. However, collagen hydrogels also have several drawbacks, such as low mechanical strength, limited ability to induce stem cell differentiation, and rapid degradation. Thus, there is a demanding need to optimize collagen hydrogels for cartilage regeneration. In this review, we will first briefly introduce the structure of articular cartilage and cartilage defect classification and collagen, then provide an overview of the progress made in research on collagen hydrogels with chondrocytes or stem cells, comprehensively expound the research progress and clinical applications of collagen‐based hydrogels that integrate inorganic or organic materials, and finally present challenges for further clinical translation.
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spelling pubmed-106940282023-12-05 Collagen‐Based Hydrogels for Cartilage Regeneration Sun, Lihui Xu, Yan Han, Yu Cui, Jing Jing, Zheng Li, Dongbo Liu, Jianguo Xiao, Chunsheng Li, Dongsong Cai, Bo Orthop Surg Review Articles Cartilage regeneration remains difficult due to a lack of blood vessels. Degradation of the extracellular matrix (ECM) causes cartilage defects, and the ECM provides the natural environment and nutrition for cartilage regeneration. Until now, collagen hydrogels are considered to be excellent material for cartilage regeneration due to the similar structure to ECM and good biocompatibility. However, collagen hydrogels also have several drawbacks, such as low mechanical strength, limited ability to induce stem cell differentiation, and rapid degradation. Thus, there is a demanding need to optimize collagen hydrogels for cartilage regeneration. In this review, we will first briefly introduce the structure of articular cartilage and cartilage defect classification and collagen, then provide an overview of the progress made in research on collagen hydrogels with chondrocytes or stem cells, comprehensively expound the research progress and clinical applications of collagen‐based hydrogels that integrate inorganic or organic materials, and finally present challenges for further clinical translation. John Wiley & Sons Australia, Ltd 2023-11-09 /pmc/articles/PMC10694028/ /pubmed/37942509 http://dx.doi.org/10.1111/os.13884 Text en © 2023 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Sun, Lihui
Xu, Yan
Han, Yu
Cui, Jing
Jing, Zheng
Li, Dongbo
Liu, Jianguo
Xiao, Chunsheng
Li, Dongsong
Cai, Bo
Collagen‐Based Hydrogels for Cartilage Regeneration
title Collagen‐Based Hydrogels for Cartilage Regeneration
title_full Collagen‐Based Hydrogels for Cartilage Regeneration
title_fullStr Collagen‐Based Hydrogels for Cartilage Regeneration
title_full_unstemmed Collagen‐Based Hydrogels for Cartilage Regeneration
title_short Collagen‐Based Hydrogels for Cartilage Regeneration
title_sort collagen‐based hydrogels for cartilage regeneration
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694028/
https://www.ncbi.nlm.nih.gov/pubmed/37942509
http://dx.doi.org/10.1111/os.13884
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