The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications

Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to gout, gouty arthritis, renal damage, and cardiovascular injury. There is a strong inflammatory response in the process of HUA, while dysregulation of immune cells, including monocytes, macrophages, and T cells,...

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Autores principales: Li, Delun, Yuan, Siyu, Deng, Yiyao, Wang, Xiaowan, Wu, Shouhai, Chen, Xuesheng, Li, Yimeng, Ouyang, Jianting, Lin, Danyao, Quan, Haohao, Fu, Xinwen, Li, Chuang, Mao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694226/
http://dx.doi.org/10.3389/fimmu.2023.1282890
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author Li, Delun
Yuan, Siyu
Deng, Yiyao
Wang, Xiaowan
Wu, Shouhai
Chen, Xuesheng
Li, Yimeng
Ouyang, Jianting
Lin, Danyao
Quan, Haohao
Fu, Xinwen
Li, Chuang
Mao, Wei
author_facet Li, Delun
Yuan, Siyu
Deng, Yiyao
Wang, Xiaowan
Wu, Shouhai
Chen, Xuesheng
Li, Yimeng
Ouyang, Jianting
Lin, Danyao
Quan, Haohao
Fu, Xinwen
Li, Chuang
Mao, Wei
author_sort Li, Delun
collection PubMed
description Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to gout, gouty arthritis, renal damage, and cardiovascular injury. There is a strong inflammatory response in the process of HUA, while dysregulation of immune cells, including monocytes, macrophages, and T cells, plays a crucial role in the inflammatory response. Recent studies have indicated that urate has a direct impact on immune cell populations, changes in cytokine expression, modifications in chemotaxis and differentiation, and the provocation of immune cells by intrinsic cells to cause the aforementioned conditions. Here we conducted a detailed review of the relationship among uric acid, immune response, and inflammatory status in hyperuricemia and its complications, providing new therapeutic targets and strategies.
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spelling pubmed-106942262023-12-05 The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications Li, Delun Yuan, Siyu Deng, Yiyao Wang, Xiaowan Wu, Shouhai Chen, Xuesheng Li, Yimeng Ouyang, Jianting Lin, Danyao Quan, Haohao Fu, Xinwen Li, Chuang Mao, Wei Front Immunol Immunology Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to gout, gouty arthritis, renal damage, and cardiovascular injury. There is a strong inflammatory response in the process of HUA, while dysregulation of immune cells, including monocytes, macrophages, and T cells, plays a crucial role in the inflammatory response. Recent studies have indicated that urate has a direct impact on immune cell populations, changes in cytokine expression, modifications in chemotaxis and differentiation, and the provocation of immune cells by intrinsic cells to cause the aforementioned conditions. Here we conducted a detailed review of the relationship among uric acid, immune response, and inflammatory status in hyperuricemia and its complications, providing new therapeutic targets and strategies. Frontiers Media S.A. 2023-11-20 /pmc/articles/PMC10694226/ http://dx.doi.org/10.3389/fimmu.2023.1282890 Text en Copyright © 2023 Li, Yuan, Deng, Wang, Wu, Chen, Li, Ouyang, Lin, Quan, Fu, Li and Mao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Delun
Yuan, Siyu
Deng, Yiyao
Wang, Xiaowan
Wu, Shouhai
Chen, Xuesheng
Li, Yimeng
Ouyang, Jianting
Lin, Danyao
Quan, Haohao
Fu, Xinwen
Li, Chuang
Mao, Wei
The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
title The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
title_full The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
title_fullStr The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
title_full_unstemmed The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
title_short The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
title_sort dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694226/
http://dx.doi.org/10.3389/fimmu.2023.1282890
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