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Noncardiac anomalies in children with congenital heart disease

INTRODUCTION: Noncardiac anomalies (NCAs) in patients with congenital heart defects (CHDs) are crucial for perioperative management and etiology studies. This study aimed to investigate NCAs in Chinese children with CHDs. METHODS: Medical records for CHD-diagnosed children hospitalized from 1 Januar...

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Autores principales: Huang, Xianghui, Gao, Yuan, Chen, Weicheng, Sheng, Wei, Huang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694264/
http://dx.doi.org/10.3389/fcvm.2023.1293210
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author Huang, Xianghui
Gao, Yuan
Chen, Weicheng
Sheng, Wei
Huang, Guoying
author_facet Huang, Xianghui
Gao, Yuan
Chen, Weicheng
Sheng, Wei
Huang, Guoying
author_sort Huang, Xianghui
collection PubMed
description INTRODUCTION: Noncardiac anomalies (NCAs) in patients with congenital heart defects (CHDs) are crucial for perioperative management and etiology studies. This study aimed to investigate NCAs in Chinese children with CHDs. METHODS: Medical records for CHD-diagnosed children hospitalized from 1 January 2015 to 31 December 2019 were collected and subjected to retrospective analyses to excavate potential association rules between CHDs and noncardiac malformations. RESULTS: A total of 3,788 CHD patients were included in this study. The main phenotypes of CHD were Ventricular Septal Defect (VSD, 33.69%), Atrial Septal Defect (ASD, 12.72%), and Tetralogy of Fallot (TOF, 5.54%). A total of 887 (23.42%) cases showed noncardiac anomalies, which were mainly associated with the central nervous system (34.61%), nose/ear/mandibular/face (19.39%), genitourinary system (15.78%), and musculoskeletal system (15.56%). Compared to other CHD subtypes, septal defects had a lower percentage of associated NCAs (P = 3.7 × 10(−9)) while AVSD had a higher percentage (P = 0.0018). DISSCUSSION: NCAs are prevalent among CHD-diagnosed children in China, and the spectrums of NCAs in different CHD subcategories were different.
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spelling pubmed-106942642023-12-05 Noncardiac anomalies in children with congenital heart disease Huang, Xianghui Gao, Yuan Chen, Weicheng Sheng, Wei Huang, Guoying Front Cardiovasc Med Cardiovascular Medicine INTRODUCTION: Noncardiac anomalies (NCAs) in patients with congenital heart defects (CHDs) are crucial for perioperative management and etiology studies. This study aimed to investigate NCAs in Chinese children with CHDs. METHODS: Medical records for CHD-diagnosed children hospitalized from 1 January 2015 to 31 December 2019 were collected and subjected to retrospective analyses to excavate potential association rules between CHDs and noncardiac malformations. RESULTS: A total of 3,788 CHD patients were included in this study. The main phenotypes of CHD were Ventricular Septal Defect (VSD, 33.69%), Atrial Septal Defect (ASD, 12.72%), and Tetralogy of Fallot (TOF, 5.54%). A total of 887 (23.42%) cases showed noncardiac anomalies, which were mainly associated with the central nervous system (34.61%), nose/ear/mandibular/face (19.39%), genitourinary system (15.78%), and musculoskeletal system (15.56%). Compared to other CHD subtypes, septal defects had a lower percentage of associated NCAs (P = 3.7 × 10(−9)) while AVSD had a higher percentage (P = 0.0018). DISSCUSSION: NCAs are prevalent among CHD-diagnosed children in China, and the spectrums of NCAs in different CHD subcategories were different. Frontiers Media S.A. 2023-11-20 /pmc/articles/PMC10694264/ http://dx.doi.org/10.3389/fcvm.2023.1293210 Text en © 2023 Huang, Gao, Chen, Sheng and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Huang, Xianghui
Gao, Yuan
Chen, Weicheng
Sheng, Wei
Huang, Guoying
Noncardiac anomalies in children with congenital heart disease
title Noncardiac anomalies in children with congenital heart disease
title_full Noncardiac anomalies in children with congenital heart disease
title_fullStr Noncardiac anomalies in children with congenital heart disease
title_full_unstemmed Noncardiac anomalies in children with congenital heart disease
title_short Noncardiac anomalies in children with congenital heart disease
title_sort noncardiac anomalies in children with congenital heart disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694264/
http://dx.doi.org/10.3389/fcvm.2023.1293210
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