Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug metabolism is difficult. Methods: Cirrhosis in mice was induced by repeated treatment with carbon tetrachloride for 12 months. A cocktail of six...

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Detalles Bibliográficos
Autores principales: Fendt, Rebekka, Ghallab, Ahmed, Myllys, Maiju, Hofmann, Ute, Hassan, Reham, Hobloss, Zaynab, González, Daniela, Brackhagen, Lisa, Marchan, Rosemarie, Edlund, Karolina, Seddek, Abdel-Latif, Abdelmageed, Noha, Blank, Lars M., Schlender, Jan-Frederik, Holland, Christian H., Hengstler, Jan G., Kuepfer, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694292/
http://dx.doi.org/10.3389/fphar.2023.1279357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694292/
http://dx.doi.org/10.3389/fphar.2023.1279357

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