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Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction
Prolonged controlled mechanical ventilation (CMV) can cause diaphragm fiber atrophy and inspiratory muscle weakness, resulting in diaphragmatic contractile dysfunction, called ventilator-induced diaphragm dysfunction (VIDD). VIDD is associated with higher rates of in-hospital deaths, nosocomial pneu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694316/ http://dx.doi.org/10.1016/j.heliyon.2023.e22317 |
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author | Zhang, Jumei Feng, Jianguo Jia, Jing Wang, Xiaobin Zhou, Jun Liu, Li |
author_facet | Zhang, Jumei Feng, Jianguo Jia, Jing Wang, Xiaobin Zhou, Jun Liu, Li |
author_sort | Zhang, Jumei |
collection | PubMed |
description | Prolonged controlled mechanical ventilation (CMV) can cause diaphragm fiber atrophy and inspiratory muscle weakness, resulting in diaphragmatic contractile dysfunction, called ventilator-induced diaphragm dysfunction (VIDD). VIDD is associated with higher rates of in-hospital deaths, nosocomial pneumonia, difficulty weaning from ventilators, and increased costs. Currently, appropriate clinical strategies to prevent and treat VIDD are unavailable, necessitating the importance of exploring the mechanisms of VIDD and suitable treatment options to reduce the healthcare burden. Numerous animal studies have demonstrated that ventilator-induced diaphragm dysfunction is associated with oxidative stress, increased protein hydrolysis, disuse atrophy, and calcium ion disorders. Therefore, this article summarizes the molecular pathogenesis and treatment of ventilator-induced diaphragm dysfunction in recent years so that it can be better served clinically and is essential to reduce the duration of mechanical ventilation use, intensive care unit (ICU) length of stay, and the medical burden. |
format | Online Article Text |
id | pubmed-10694316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106943162023-12-05 Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction Zhang, Jumei Feng, Jianguo Jia, Jing Wang, Xiaobin Zhou, Jun Liu, Li Heliyon Review Article Prolonged controlled mechanical ventilation (CMV) can cause diaphragm fiber atrophy and inspiratory muscle weakness, resulting in diaphragmatic contractile dysfunction, called ventilator-induced diaphragm dysfunction (VIDD). VIDD is associated with higher rates of in-hospital deaths, nosocomial pneumonia, difficulty weaning from ventilators, and increased costs. Currently, appropriate clinical strategies to prevent and treat VIDD are unavailable, necessitating the importance of exploring the mechanisms of VIDD and suitable treatment options to reduce the healthcare burden. Numerous animal studies have demonstrated that ventilator-induced diaphragm dysfunction is associated with oxidative stress, increased protein hydrolysis, disuse atrophy, and calcium ion disorders. Therefore, this article summarizes the molecular pathogenesis and treatment of ventilator-induced diaphragm dysfunction in recent years so that it can be better served clinically and is essential to reduce the duration of mechanical ventilation use, intensive care unit (ICU) length of stay, and the medical burden. Elsevier 2023-11-14 /pmc/articles/PMC10694316/ http://dx.doi.org/10.1016/j.heliyon.2023.e22317 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Zhang, Jumei Feng, Jianguo Jia, Jing Wang, Xiaobin Zhou, Jun Liu, Li Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
title | Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
title_full | Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
title_fullStr | Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
title_full_unstemmed | Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
title_short | Research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
title_sort | research progress on the pathogenesis and treatment of ventilator-induced diaphragm dysfunction |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694316/ http://dx.doi.org/10.1016/j.heliyon.2023.e22317 |
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