Novel combinatorial therapy of oncolytic adenovirus AdV5/3-D24-ICOSL-CD40L with anti PD-1 exhibits enhanced anti-cancer efficacy through promotion of intratumoral T-cell infiltration and modulation of tumour microenvironment in mesothelioma mouse model

INTRODUCTION: Malignant mesothelioma is a rare and aggressive form of cancer. Despite improvements in cancer treatment, there are still no curative treatment modalities for advanced stage of the malignancy. The aim of this study was to evaluate the anti-tumor efficacy of a novel combinatorial therap...

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Detalles Bibliográficos
Autores principales: Garofalo, Mariangela, Wieczorek, Magdalena, Anders, Ines, Staniszewska, Monika, Lazniewski, Michal, Prygiel, Marta, Zasada, Aleksandra Anna, Szczepińska, Teresa, Plewczynski, Dariusz, Salmaso, Stefano, Caliceti, Paolo, Cerullo, Vincenzo, Alemany, Ramon, Rinner, Beate, Pancer, Katarzyna, Kuryk, Lukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694471/
http://dx.doi.org/10.3389/fonc.2023.1259314

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