Cytokine profiles in an extremely preterm infant with congenital syphilis

We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother’s treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supp...

Descripción completa

Detalles Bibliográficos
Autores principales: Fukama, Eisuke, Nomura, Tomoaki, Hatanaka, Daisuke, Kusakari, Michiko, Takahashi, Hidehiro, Nakamura, Toshihiko, Takahashi, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Fukushima Society of Medical Science 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694514/
https://www.ncbi.nlm.nih.gov/pubmed/37766559
http://dx.doi.org/10.5387/fms.2023-06
_version_ 1785153395502350336
author Fukama, Eisuke
Nomura, Tomoaki
Hatanaka, Daisuke
Kusakari, Michiko
Takahashi, Hidehiro
Nakamura, Toshihiko
Takahashi, Naoto
author_facet Fukama, Eisuke
Nomura, Tomoaki
Hatanaka, Daisuke
Kusakari, Michiko
Takahashi, Hidehiro
Nakamura, Toshihiko
Takahashi, Naoto
author_sort Fukama, Eisuke
collection PubMed
description We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother’s treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supports immunological mechanisms of Th-1, was similar to that in cases of syphilis in adults. IL-6 and granulocyte colony-stimulating factor (G-CSF), the synergistic effects of which cause the leukemoid reaction, were also elevated. The levels of interferon-γ and IL-17 in cerebral spinal fluid, which are elevated in neurosyphilis in adults, were slightly elevated.
format Online
Article
Text
id pubmed-10694514
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Fukushima Society of Medical Science
record_format MEDLINE/PubMed
spelling pubmed-106945142023-12-05 Cytokine profiles in an extremely preterm infant with congenital syphilis Fukama, Eisuke Nomura, Tomoaki Hatanaka, Daisuke Kusakari, Michiko Takahashi, Hidehiro Nakamura, Toshihiko Takahashi, Naoto Fukushima J Med Sci Case Report We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother’s treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supports immunological mechanisms of Th-1, was similar to that in cases of syphilis in adults. IL-6 and granulocyte colony-stimulating factor (G-CSF), the synergistic effects of which cause the leukemoid reaction, were also elevated. The levels of interferon-γ and IL-17 in cerebral spinal fluid, which are elevated in neurosyphilis in adults, were slightly elevated. The Fukushima Society of Medical Science 2023-09-28 2023 /pmc/articles/PMC10694514/ /pubmed/37766559 http://dx.doi.org/10.5387/fms.2023-06 Text en © 2023 The Fukushima Society of Medical Science https://creativecommons.org/licenses/by-nc-sa/4.0/This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. https://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Case Report
Fukama, Eisuke
Nomura, Tomoaki
Hatanaka, Daisuke
Kusakari, Michiko
Takahashi, Hidehiro
Nakamura, Toshihiko
Takahashi, Naoto
Cytokine profiles in an extremely preterm infant with congenital syphilis
title Cytokine profiles in an extremely preterm infant with congenital syphilis
title_full Cytokine profiles in an extremely preterm infant with congenital syphilis
title_fullStr Cytokine profiles in an extremely preterm infant with congenital syphilis
title_full_unstemmed Cytokine profiles in an extremely preterm infant with congenital syphilis
title_short Cytokine profiles in an extremely preterm infant with congenital syphilis
title_sort cytokine profiles in an extremely preterm infant with congenital syphilis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694514/
https://www.ncbi.nlm.nih.gov/pubmed/37766559
http://dx.doi.org/10.5387/fms.2023-06
work_keys_str_mv AT fukamaeisuke cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis
AT nomuratomoaki cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis
AT hatanakadaisuke cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis
AT kusakarimichiko cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis
AT takahashihidehiro cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis
AT nakamuratoshihiko cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis
AT takahashinaoto cytokineprofilesinanextremelypreterminfantwithcongenitalsyphilis

Ejemplares similares