Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.

Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular involvement and the first analysis of all previously reported cases assessing trends in immunohistochemical features, pro...

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Autores principales: Alkhalili, Samer, Manogna, Dharmini, Safah, Hana, Ellent, Elizabeth, Beversdorf, Walter, Arora, Ruby, Saba, Nakhle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694562/
http://dx.doi.org/10.1016/j.lrr.2023.100397
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author Alkhalili, Samer
Manogna, Dharmini
Safah, Hana
Ellent, Elizabeth
Beversdorf, Walter
Arora, Ruby
Saba, Nakhle S.
author_facet Alkhalili, Samer
Manogna, Dharmini
Safah, Hana
Ellent, Elizabeth
Beversdorf, Walter
Arora, Ruby
Saba, Nakhle S.
author_sort Alkhalili, Samer
collection PubMed
description Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular involvement and the first analysis of all previously reported cases assessing trends in immunohistochemical features, prognostic indicators, and survival. Our data suggest that among all MCL, testicular MCL is more likely to present with aggressive features: blastoid/pleomorphic morphology, high Ki-67 proliferative index, and CNS involvement. Testicular MCL is also associated with shorter overall survival.
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spelling pubmed-106945622023-12-05 Testicular involvement in mantle cell lymphoma: An analysis of 16 patients. Alkhalili, Samer Manogna, Dharmini Safah, Hana Ellent, Elizabeth Beversdorf, Walter Arora, Ruby Saba, Nakhle S. Leuk Res Rep Article Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular involvement and the first analysis of all previously reported cases assessing trends in immunohistochemical features, prognostic indicators, and survival. Our data suggest that among all MCL, testicular MCL is more likely to present with aggressive features: blastoid/pleomorphic morphology, high Ki-67 proliferative index, and CNS involvement. Testicular MCL is also associated with shorter overall survival. Elsevier 2023-11-15 /pmc/articles/PMC10694562/ http://dx.doi.org/10.1016/j.lrr.2023.100397 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Alkhalili, Samer
Manogna, Dharmini
Safah, Hana
Ellent, Elizabeth
Beversdorf, Walter
Arora, Ruby
Saba, Nakhle S.
Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.
title Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.
title_full Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.
title_fullStr Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.
title_full_unstemmed Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.
title_short Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.
title_sort testicular involvement in mantle cell lymphoma: an analysis of 16 patients.
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694562/
http://dx.doi.org/10.1016/j.lrr.2023.100397
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