High-throughput functional analysis of regulatory variants using a massively parallel reporter assay

Association studies describe genetic associations between noncoding variants and disease susceptibility; however, they do not provide functional insight into the underlying molecular mechanisms of these variants. We present a protocol to assay the regulatory potential of thousands of noncoding varia...

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Detalles Bibliográficos
Autores principales: Delfosse, Kate, Gerhardinger, Chiara, Rinn, John L., Maass, Philipp G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694570/
https://www.ncbi.nlm.nih.gov/pubmed/37980569
http://dx.doi.org/10.1016/j.xpro.2023.102731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694570/
https://www.ncbi.nlm.nih.gov/pubmed/37980569
http://dx.doi.org/10.1016/j.xpro.2023.102731

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