Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease

Despite potential impact on the graft vs. leukemia (GVL) effect, immunotherapy targeting CTLA-4 and/or PD-1 has not been successfully combined with bone marrow transplant (BMT) because it exacerbates graft vs. host disease (GVHD). Here, using models of GVHD and leukemia, we demonstrate that targetin...

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Detalles Bibliográficos
Autores principales: Bailey, Christopher, Wei, Yuanyi, Yan, Jinsong, Huang, Dan, Zhang, Peng, Qi, Chong, Lazarski, Christopher, Su, JuanJuan, Tang, Fei, Wong, Chun-shu, Zheng, Pan, Liu, Yan, Liu, Yang, Wang, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694596/
https://www.ncbi.nlm.nih.gov/pubmed/37827154
http://dx.doi.org/10.1016/j.xcrm.2023.101236

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