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Deep immunological imprinting due to the ancestral spike in the current bivalent COVID-19 vaccine

To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines, encoding both ancestral and Omicron BA.5 spikes, have replaced monovalent vaccines in numerous countries. However, fourth doses of either vaccine result in similar neutralizing antibody titers against Omicron subvar...

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Detalles Bibliográficos
Autores principales:	Wang, Qian, Guo, Yicheng, Tam, Anthony R., Valdez, Riccardo, Gordon, Aubree, Liu, Lihong, Ho, David D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694617/ https://www.ncbi.nlm.nih.gov/pubmed/37909042 http://dx.doi.org/10.1016/j.xcrm.2023.101258

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