Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins

Defects in homologous recombination DNA repair (HRD) both predispose to cancer development and produce therapeutic vulnerabilities, making it critical to define the spectrum of genetic events that cause HRD. However, we found that mutations in BRCA1/2 and other canonical HR genes only identified 10%...

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Detalles Bibliográficos
Autores principales: McGrail, Daniel J., Li, Yang, Smith, Roger S., Feng, Bin, Dai, Hui, Hu, Limei, Dennehey, Briana, Awasthi, Sharad, Mendillo, Marc L., Sood, Anil K., Mills, Gordon B., Lin, Shiaw-Yih, Yi, S. Stephen, Sahni, Nidhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694618/
https://www.ncbi.nlm.nih.gov/pubmed/37909041
http://dx.doi.org/10.1016/j.xcrm.2023.101255

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