Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma

ARID1A is among the most commonly mutated tumor suppressor genes in hepatocellular carcinoma (HCC). In this study, we conduct a CRISPR-Cas9 synthetic lethality screen using ARID1A-deficient HCC cells to identify approaches to treat HCC patients harboring ARID1A deficiency. This strategy reveals that...

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Detalles Bibliográficos
Autores principales: Xing, Tao, Li, Li, Chen, Yiran, Ju, Gaoda, Li, Guilan, Zhu, Xiaoyun, Ren, Yubo, Zhao, Jing, Cheng, Zhilei, Li, Yan, Xu, Da, Liang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694624/
https://www.ncbi.nlm.nih.gov/pubmed/37939712
http://dx.doi.org/10.1016/j.xcrm.2023.101264

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