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Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes

In preclinical models, α-difluoromethylornithine (DFMO), an ornithine decarboxylase (ODC) inhibitor, delays the onset of type 1 diabetes (T1D) by reducing β cell stress. However, the mechanism of DFMO action and its human tolerability remain unclear. In this study, we show that mice with β cell ODC...

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Detalles Bibliográficos
Autores principales:	Sims, Emily K., Kulkarni, Abhishek, Hull, Audrey, Woerner, Stephanie E., Cabrera, Susanne, Mastrandrea, Lucy D., Hammoud, Batoul, Sarkar, Soumyadeep, Nakayasu, Ernesto S., Mastracci, Teresa L., Perkins, Susan M., Ouyang, Fangqian, Webb-Robertson, Bobbie-Jo, Enriquez, Jacob R., Tersey, Sarah A., Evans-Molina, Carmella, Long, S. Alice, Blanchfield, Lori, Gerner, Eugene W., Mirmira, Raghavendra G., DiMeglio, Linda A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694631/ https://www.ncbi.nlm.nih.gov/pubmed/37918404 http://dx.doi.org/10.1016/j.xcrm.2023.101261

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