Amyloid-β(1-42) oligomers enhance mGlu(5)R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling

Synaptic weakening and loss are well-correlated with the pathology of Alzheimer’s disease (AD). Oligomeric amyloid beta (oAβ) is considered a major synaptotoxic trigger for AD. Recent studies have implicated hyperactivation of the complement cascade as the driving force for loss of synapses caused b...

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Detalles Bibliográficos
Autores principales: Ng, Ai Na, Salter, Eric W., Georgiou, John, Bortolotto, Zuner A., Collingridge, Graham L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694656/
http://dx.doi.org/10.1016/j.isci.2023.108412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694656/
http://dx.doi.org/10.1016/j.isci.2023.108412

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