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Tipping the GVH/GVL balance by targeting HIF1α
Promoting GVL activity while eliminating GVHD is the utmost goal to treat hematological malignancies with allo-HCT. Bailey et al. demonstrate that targeting HIF1α can favor GVL activity while limiting GVHD after allo-HCT even in combination with immune checkpoint inhibition.(1)
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694739/ https://www.ncbi.nlm.nih.gov/pubmed/37992679 http://dx.doi.org/10.1016/j.xcrm.2023.101295 |
| _version_ | 1785153444718313472 |
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| author | Wu, Yongxia Yu, Xue-Zhong |
| author_facet | Wu, Yongxia Yu, Xue-Zhong |
| author_sort | Wu, Yongxia |
| collection | PubMed |
| description | Promoting GVL activity while eliminating GVHD is the utmost goal to treat hematological malignancies with allo-HCT. Bailey et al. demonstrate that targeting HIF1α can favor GVL activity while limiting GVHD after allo-HCT even in combination with immune checkpoint inhibition.(1) |
| format | Online Article Text |
| id | pubmed-10694739 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-106947392023-12-05 Tipping the GVH/GVL balance by targeting HIF1α Wu, Yongxia Yu, Xue-Zhong Cell Rep Med Preview Promoting GVL activity while eliminating GVHD is the utmost goal to treat hematological malignancies with allo-HCT. Bailey et al. demonstrate that targeting HIF1α can favor GVL activity while limiting GVHD after allo-HCT even in combination with immune checkpoint inhibition.(1) Elsevier 2023-11-21 /pmc/articles/PMC10694739/ /pubmed/37992679 http://dx.doi.org/10.1016/j.xcrm.2023.101295 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Preview Wu, Yongxia Yu, Xue-Zhong Tipping the GVH/GVL balance by targeting HIF1α |
| title | Tipping the GVH/GVL balance by targeting HIF1α |
| title_full | Tipping the GVH/GVL balance by targeting HIF1α |
| title_fullStr | Tipping the GVH/GVL balance by targeting HIF1α |
| title_full_unstemmed | Tipping the GVH/GVL balance by targeting HIF1α |
| title_short | Tipping the GVH/GVL balance by targeting HIF1α |
| title_sort | tipping the gvh/gvl balance by targeting hif1α |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694739/ https://www.ncbi.nlm.nih.gov/pubmed/37992679 http://dx.doi.org/10.1016/j.xcrm.2023.101295 |
| work_keys_str_mv | AT wuyongxia tippingthegvhgvlbalancebytargetinghif1a AT yuxuezhong tippingthegvhgvlbalancebytargetinghif1a |