Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

Mutations in the receptor tyrosine kinases (RTKs) FLT3 and KIT are frequent and associated with poor outcomes in acute myeloid leukemia (AML). Although selective FLT3 inhibitors (FLT3i) are clinically effective, remissions are short-lived due to secondary resistance characterized by acquired mutatio...

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Detalles Bibliográficos
Autores principales: Popescu, Bogdan, Stahlhut, Carlos, Tarver, Theodore C., Wishner, Sydney, Lee, Bianca J., Peretz, Cheryl A.C., Luck, Cuyler, Phojanakong, Paul, Camara Serrano, Juan Antonio, Hongo, Henry, Rivera, Jose M., Xirenayi, Simayijiang, Chukinas, John A., Steri, Veronica, Tasian, Sarah K., Stieglitz, Elliot, Smith, Catherine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694768/
https://www.ncbi.nlm.nih.gov/pubmed/37992684
http://dx.doi.org/10.1016/j.xcrm.2023.101290

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