Silencing of genes by promoter hypermethylation shapes tumor microenvironment and resistance to immunotherapy in clear-cell renal cell carcinomas

The efficacy of immune checkpoint inhibitors varies in clear-cell renal cell carcinoma (ccRCC), with notable primary resistance among patients. Here, we integrate epigenetic (DNA methylation) and transcriptome data to identify a ccRCC subtype characterized by cancer-specific promoter hypermethylatio...

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Detalles Bibliográficos
Autores principales: Lu, Xiaofan, Vano, Yann-Alexandre, Su, Xiaoping, Helleux, Alexandra, Lindner, Véronique, Mouawad, Roger, Spano, Jean-Philippe, Rouprêt, Morgan, Compérat, Eva, Verkarre, Virginie, Sun, Cheng-Ming, Bennamoun, Mostefa, Lang, Hervé, Barthelemy, Philippe, Cheng, Wenxuan, Xu, Li, Davidson, Irwin, Yan, Fangrong, Fridman, Wolf Hervé, Sautes-Fridman, Catherine, Oudard, Stéphane, Malouf, Gabriel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694769/
https://www.ncbi.nlm.nih.gov/pubmed/37967556
http://dx.doi.org/10.1016/j.xcrm.2023.101287

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