Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy

We used electron cryo-microscopy (cryo-EM) to determine the structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer’s disease and cerebral amyloid angiopathy. In agreement with previously reported structures, which were solved to a resolution of 4.4 Å, we found three types...

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Detalles Bibliográficos
Autores principales: Yang, Yang, Murzin, Alexey G., Peak-Chew, Sew, Franco, Catarina, Garringer, Holly J., Newell, Kathy L., Ghetti, Bernardino, Goedert, Michel, Scheres, Sjors H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694933/
https://www.ncbi.nlm.nih.gov/pubmed/38049918
http://dx.doi.org/10.1186/s40478-023-01694-8

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