Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

BACKGROUND: Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered by ceramide enrichment at the plasma membrane from neutr...

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Detalles Bibliográficos
Autores principales: Tallon, Carolyn, Bell, Benjamin J., Malvankar, Medhinee M., Deme, Pragney, Nogueras-Ortiz, Carlos, Eren, Erden, Thomas, Ajit G., Hollinger, Kristen R., Pal, Arindom, Mustapic, Maja, Huang, Meixiang, Coleman, Kaleem, Joe, Tawnjerae R., Rais, Rana, Haughey, Norman J., Kapogiannis, Dimitrios, Slusher, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694940/
https://www.ncbi.nlm.nih.gov/pubmed/38049923
http://dx.doi.org/10.1186/s40035-023-00383-9

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