Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration

BACKGROUND: Dexamethasone (DEX) induces CYP3A activity in a concentration-dependent manner. However, no study has examined changes in the blood concentration of CYP3A substrate drugs when DEX is administered at high doses. Herein, we present a case in which tacrolimus (TAC), a typical CYP3A substrat...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohno, Yoshiyuki, Oriyama, Toyohito, Honda, Akira, Kurokawa, Mineo, Takada, Tappei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694947/
https://www.ncbi.nlm.nih.gov/pubmed/38044431
http://dx.doi.org/10.1186/s40780-023-00310-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694947/
https://www.ncbi.nlm.nih.gov/pubmed/38044431
http://dx.doi.org/10.1186/s40780-023-00310-0

Ejemplares similares