Cargando…
Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial
BACKGROUND: Minimal pain and opioid use after operative treatment for pediatric supracondylar humeral fractures have been previously described; however, opioid-prescribing practices in the United States remain variable. We hypothesized that children without an opioid prescription would report simila...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Journal of Bone and Joint Surgery, Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695340/ https://www.ncbi.nlm.nih.gov/pubmed/37956188 http://dx.doi.org/10.2106/JBJS.23.00223 |
_version_ | 1785153546419699712 |
---|---|
author | Belardo, Zoe E. Talwar, Divya Blumberg, Todd J. Nelson, Susan E. Upasani, Vidyadhar V. Sankar, Wudbhav N. Shah, Apurva S. |
author_facet | Belardo, Zoe E. Talwar, Divya Blumberg, Todd J. Nelson, Susan E. Upasani, Vidyadhar V. Sankar, Wudbhav N. Shah, Apurva S. |
author_sort | Belardo, Zoe E. |
collection | PubMed |
description | BACKGROUND: Minimal pain and opioid use after operative treatment for pediatric supracondylar humeral fractures have been previously described; however, opioid-prescribing practices in the United States remain variable. We hypothesized that children without an opioid prescription would report similar postoperative pain compared with children prescribed opioids following closed reduction and percutaneous pinning (CRPP) of supracondylar humeral fractures. METHODS: Children who were 3 to 12 years of age and were undergoing CRPP for a closed supracondylar humeral fracture were prospectively enrolled in a multicenter, comparative study. Following a standardized dosing protocol, oxycodone, ibuprofen, and acetaminophen were prescribed at 2 hospitals (opioid cohort), and 2 other hospitals prescribed ibuprofen and acetaminophen alone (non-opioid cohort). The children’s medication use and the daily pain that they experienced (scored on the Wong-Baker FACES Scale) were recorded at postoperative days 1 to 7, 10, 14, and 21, using validated text-message protocols. Based on an a priori power analysis, at least 64 evaluable subjects were recruited per cohort. RESULTS: A total of 157 patients were evaluated (81 [52%] in the opioid cohort and 76 [48%] in the non-opioid cohort). The median age at the time of the surgical procedure was 6.2 years, and 50% of the subjects were male. The mean postoperative pain scores were low overall (<4 of 10), and there were no significant differences in pain ratings between cohorts at any time point. No patient demographic or injury characteristics were correlated with increased pain or medication use. Notably, of the 81 patients in the opioid cohort, 28 (35%) took no oxycodone and 40 (49%) took 1 to 3 total doses across the postoperative period. Patients rarely took opioids after postoperative day 2. A single patient in the non-opioid cohort (1 [1%] of 76) received a rescue prescription of opioids after presenting to the emergency department with postoperative cast discomfort. CONCLUSIONS: Non-opioid analgesia following CRPP for pediatric supracondylar humeral fractures was equally effective as opioid analgesia. When oxycodone was prescribed, 84% of children took 0 to 3 total doses, and opioid use fell precipitously after postoperative day 2. To improve opioid stewardship, providers and institutions can consider discontinuing the routine prescription of opioids following this procedure. LEVEL OF EVIDENCE: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence. |
format | Online Article Text |
id | pubmed-10695340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Journal of Bone and Joint Surgery, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106953402023-12-05 Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial Belardo, Zoe E. Talwar, Divya Blumberg, Todd J. Nelson, Susan E. Upasani, Vidyadhar V. Sankar, Wudbhav N. Shah, Apurva S. J Bone Joint Surg Am Scientific Articles BACKGROUND: Minimal pain and opioid use after operative treatment for pediatric supracondylar humeral fractures have been previously described; however, opioid-prescribing practices in the United States remain variable. We hypothesized that children without an opioid prescription would report similar postoperative pain compared with children prescribed opioids following closed reduction and percutaneous pinning (CRPP) of supracondylar humeral fractures. METHODS: Children who were 3 to 12 years of age and were undergoing CRPP for a closed supracondylar humeral fracture were prospectively enrolled in a multicenter, comparative study. Following a standardized dosing protocol, oxycodone, ibuprofen, and acetaminophen were prescribed at 2 hospitals (opioid cohort), and 2 other hospitals prescribed ibuprofen and acetaminophen alone (non-opioid cohort). The children’s medication use and the daily pain that they experienced (scored on the Wong-Baker FACES Scale) were recorded at postoperative days 1 to 7, 10, 14, and 21, using validated text-message protocols. Based on an a priori power analysis, at least 64 evaluable subjects were recruited per cohort. RESULTS: A total of 157 patients were evaluated (81 [52%] in the opioid cohort and 76 [48%] in the non-opioid cohort). The median age at the time of the surgical procedure was 6.2 years, and 50% of the subjects were male. The mean postoperative pain scores were low overall (<4 of 10), and there were no significant differences in pain ratings between cohorts at any time point. No patient demographic or injury characteristics were correlated with increased pain or medication use. Notably, of the 81 patients in the opioid cohort, 28 (35%) took no oxycodone and 40 (49%) took 1 to 3 total doses across the postoperative period. Patients rarely took opioids after postoperative day 2. A single patient in the non-opioid cohort (1 [1%] of 76) received a rescue prescription of opioids after presenting to the emergency department with postoperative cast discomfort. CONCLUSIONS: Non-opioid analgesia following CRPP for pediatric supracondylar humeral fractures was equally effective as opioid analgesia. When oxycodone was prescribed, 84% of children took 0 to 3 total doses, and opioid use fell precipitously after postoperative day 2. To improve opioid stewardship, providers and institutions can consider discontinuing the routine prescription of opioids following this procedure. LEVEL OF EVIDENCE: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence. Journal of Bone and Joint Surgery, Inc. 2023-12-06 2023-10-23 /pmc/articles/PMC10695340/ /pubmed/37956188 http://dx.doi.org/10.2106/JBJS.23.00223 Text en Copyright © 2023 The Authors. Published by The Journal of Bone and Joint Surgery, Incorporated. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CC-BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Scientific Articles Belardo, Zoe E. Talwar, Divya Blumberg, Todd J. Nelson, Susan E. Upasani, Vidyadhar V. Sankar, Wudbhav N. Shah, Apurva S. Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial |
title | Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial |
title_full | Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial |
title_fullStr | Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial |
title_full_unstemmed | Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial |
title_short | Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial |
title_sort | opioid analgesia compared with non-opioid analgesia after operative treatment for pediatric supracondylar humeral fractures: results from a prospective multicenter trial |
topic | Scientific Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695340/ https://www.ncbi.nlm.nih.gov/pubmed/37956188 http://dx.doi.org/10.2106/JBJS.23.00223 |
work_keys_str_mv | AT belardozoee opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial AT talwardivya opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial AT blumbergtoddj opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial AT nelsonsusane opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial AT upasanividyadharv opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial AT sankarwudbhavn opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial AT shahapurvas opioidanalgesiacomparedwithnonopioidanalgesiaafteroperativetreatmentforpediatricsupracondylarhumeralfracturesresultsfromaprospectivemulticentertrial |