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Network-level changes in the brain underlie fear memory strength
The strength of a fear memory significantly influences whether it drives adaptive or maladaptive behavior in the future. Yet, how mild and strong fear memories differ in underlying biology is not well understood. We hypothesized that this distinction may not be exclusively the result of changes with...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695559/ https://www.ncbi.nlm.nih.gov/pubmed/38047914 http://dx.doi.org/10.7554/eLife.88172 |
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author | Haubrich, Josue Nader, Karim |
author_facet | Haubrich, Josue Nader, Karim |
author_sort | Haubrich, Josue |
collection | PubMed |
description | The strength of a fear memory significantly influences whether it drives adaptive or maladaptive behavior in the future. Yet, how mild and strong fear memories differ in underlying biology is not well understood. We hypothesized that this distinction may not be exclusively the result of changes within specific brain regions, but rather the outcome of collective changes in connectivity across multiple regions within the neural network. To test this, rats were fear conditioned in protocols of varying intensities to generate mild or strong memories. Neuronal activation driven by recall was measured using c-fos immunohistochemistry in 12 brain regions implicated in fear learning and memory. The interregional coordinated brain activity was computed and graph-based functional networks were generated to compare how mild and strong fear memories differ at the systems level. Our results show that mild fear recall is supported by a well-connected brain network with small-world properties in which the amygdala is well-positioned to be modulated by other regions. In contrast, this connectivity is disrupted in strong fear memories and the amygdala is isolated from other regions. These findings indicate that the neural systems underlying mild and strong fear memories differ, with implications for understanding and treating disorders of fear dysregulation. |
format | Online Article Text |
id | pubmed-10695559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-106955592023-12-05 Network-level changes in the brain underlie fear memory strength Haubrich, Josue Nader, Karim eLife Neuroscience The strength of a fear memory significantly influences whether it drives adaptive or maladaptive behavior in the future. Yet, how mild and strong fear memories differ in underlying biology is not well understood. We hypothesized that this distinction may not be exclusively the result of changes within specific brain regions, but rather the outcome of collective changes in connectivity across multiple regions within the neural network. To test this, rats were fear conditioned in protocols of varying intensities to generate mild or strong memories. Neuronal activation driven by recall was measured using c-fos immunohistochemistry in 12 brain regions implicated in fear learning and memory. The interregional coordinated brain activity was computed and graph-based functional networks were generated to compare how mild and strong fear memories differ at the systems level. Our results show that mild fear recall is supported by a well-connected brain network with small-world properties in which the amygdala is well-positioned to be modulated by other regions. In contrast, this connectivity is disrupted in strong fear memories and the amygdala is isolated from other regions. These findings indicate that the neural systems underlying mild and strong fear memories differ, with implications for understanding and treating disorders of fear dysregulation. eLife Sciences Publications, Ltd 2023-12-04 /pmc/articles/PMC10695559/ /pubmed/38047914 http://dx.doi.org/10.7554/eLife.88172 Text en © 2023, Haubrich and Nader https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Haubrich, Josue Nader, Karim Network-level changes in the brain underlie fear memory strength |
title | Network-level changes in the brain underlie fear memory strength |
title_full | Network-level changes in the brain underlie fear memory strength |
title_fullStr | Network-level changes in the brain underlie fear memory strength |
title_full_unstemmed | Network-level changes in the brain underlie fear memory strength |
title_short | Network-level changes in the brain underlie fear memory strength |
title_sort | network-level changes in the brain underlie fear memory strength |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695559/ https://www.ncbi.nlm.nih.gov/pubmed/38047914 http://dx.doi.org/10.7554/eLife.88172 |
work_keys_str_mv | AT haubrichjosue networklevelchangesinthebrainunderliefearmemorystrength AT naderkarim networklevelchangesinthebrainunderliefearmemorystrength |