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Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants

Little information is available regarding incidence and severity of pulmonary embolism (PE) across the periods of ancestral strain, Alpha, Delta, and Omicron variants. The aim of this study is to investigate the incidence and severity of PE over the dominant periods of ancestral strain and Alpha, De...

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Autores principales: Wada, Noriaki, Li, Yi, Gagne, Staci, Hino, Takuya, Valtchinov, Vladimir I., Gay, Elizabeth, Nishino, Mizuki, Hammer, Mark M., Madore, Bruno, Guttmann, Charles R. G., Ishigami, Kousei, Hunninghake, Gary M., Levy, Bruce D., Kaye, Kenneth M., Christiani, David C., Hatabu, Hiroto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695578/
http://dx.doi.org/10.1097/MD.0000000000036417
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author Wada, Noriaki
Li, Yi
Gagne, Staci
Hino, Takuya
Valtchinov, Vladimir I.
Gay, Elizabeth
Nishino, Mizuki
Hammer, Mark M.
Madore, Bruno
Guttmann, Charles R. G.
Ishigami, Kousei
Hunninghake, Gary M.
Levy, Bruce D.
Kaye, Kenneth M.
Christiani, David C.
Hatabu, Hiroto
author_facet Wada, Noriaki
Li, Yi
Gagne, Staci
Hino, Takuya
Valtchinov, Vladimir I.
Gay, Elizabeth
Nishino, Mizuki
Hammer, Mark M.
Madore, Bruno
Guttmann, Charles R. G.
Ishigami, Kousei
Hunninghake, Gary M.
Levy, Bruce D.
Kaye, Kenneth M.
Christiani, David C.
Hatabu, Hiroto
author_sort Wada, Noriaki
collection PubMed
description Little information is available regarding incidence and severity of pulmonary embolism (PE) across the periods of ancestral strain, Alpha, Delta, and Omicron variants. The aim of this study is to investigate the incidence and severity of PE over the dominant periods of ancestral strain and Alpha, Delta, and Omicron variants. We hypothesized that the incidence and the severity by proximity of PE in patients with the newer variants and vaccination would be decreased compared with those in ancestral and earlier variants. Patients with COVID-19 diagnosis between March 2020 and February 2022 and computed tomography pulmonary angiogram performed within a 6-week window around the diagnosis (−2 to +4 weeks) were studied retrospectively. The primary endpoints were the associations of the incidence and location of PE with the ancestral strain and each variant. Of the 720 coronavirus disease 2019 patients with computed tomography pulmonary angiogram (58.6 ± 17.2 years; 374 females), PE was diagnosed among 42/358 (12%) during the ancestral strain period, 5/60 (8%) during the Alpha variant period, 16/152 (11%) during the Delta variant period, and 13/150 (9%) during the Omicron variant period. The most proximal PE (ancestral strain vs variants) was located in the main/lobar arteries (31% vs 6%–40%), in the segmental arteries (52% vs 60%–75%), and in the subsegmental arteries (17% vs 0%–19%). There was no significant difference in both the incidence and location of PE across the periods, confirmed by multivariable logistic regression models. In summary, the incidence and severity of PE did not significantly differ across the periods of ancestral strain and Alpha, Delta, and Omicron variants.
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spelling pubmed-106955782023-12-05 Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants Wada, Noriaki Li, Yi Gagne, Staci Hino, Takuya Valtchinov, Vladimir I. Gay, Elizabeth Nishino, Mizuki Hammer, Mark M. Madore, Bruno Guttmann, Charles R. G. Ishigami, Kousei Hunninghake, Gary M. Levy, Bruce D. Kaye, Kenneth M. Christiani, David C. Hatabu, Hiroto Medicine (Baltimore) 6800 Little information is available regarding incidence and severity of pulmonary embolism (PE) across the periods of ancestral strain, Alpha, Delta, and Omicron variants. The aim of this study is to investigate the incidence and severity of PE over the dominant periods of ancestral strain and Alpha, Delta, and Omicron variants. We hypothesized that the incidence and the severity by proximity of PE in patients with the newer variants and vaccination would be decreased compared with those in ancestral and earlier variants. Patients with COVID-19 diagnosis between March 2020 and February 2022 and computed tomography pulmonary angiogram performed within a 6-week window around the diagnosis (−2 to +4 weeks) were studied retrospectively. The primary endpoints were the associations of the incidence and location of PE with the ancestral strain and each variant. Of the 720 coronavirus disease 2019 patients with computed tomography pulmonary angiogram (58.6 ± 17.2 years; 374 females), PE was diagnosed among 42/358 (12%) during the ancestral strain period, 5/60 (8%) during the Alpha variant period, 16/152 (11%) during the Delta variant period, and 13/150 (9%) during the Omicron variant period. The most proximal PE (ancestral strain vs variants) was located in the main/lobar arteries (31% vs 6%–40%), in the segmental arteries (52% vs 60%–75%), and in the subsegmental arteries (17% vs 0%–19%). There was no significant difference in both the incidence and location of PE across the periods, confirmed by multivariable logistic regression models. In summary, the incidence and severity of PE did not significantly differ across the periods of ancestral strain and Alpha, Delta, and Omicron variants. Lippincott Williams & Wilkins 2023-12-01 /pmc/articles/PMC10695578/ http://dx.doi.org/10.1097/MD.0000000000036417 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 6800
Wada, Noriaki
Li, Yi
Gagne, Staci
Hino, Takuya
Valtchinov, Vladimir I.
Gay, Elizabeth
Nishino, Mizuki
Hammer, Mark M.
Madore, Bruno
Guttmann, Charles R. G.
Ishigami, Kousei
Hunninghake, Gary M.
Levy, Bruce D.
Kaye, Kenneth M.
Christiani, David C.
Hatabu, Hiroto
Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants
title Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants
title_full Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants
title_fullStr Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants
title_full_unstemmed Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants
title_short Incidence and severity of pulmonary embolism in COVID-19 infection: Ancestral, Alpha, Delta, and Omicron variants
title_sort incidence and severity of pulmonary embolism in covid-19 infection: ancestral, alpha, delta, and omicron variants
topic 6800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695578/
http://dx.doi.org/10.1097/MD.0000000000036417
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