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Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis.
BACKGROUND: Regarding the thermal ablation treatment of refractory secondary hyperparathyroidism (SHPT), there is no consensus on the ablation range of the hyperplastic parathyroid gland. Therefore, this meta-analysis was conducted to evaluate the efficacy and complications between full and partial...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695584/ http://dx.doi.org/10.1097/MD.0000000000036422 |
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author | Gong, Lifeng Liu, Xiaowu Yang, Qichao Jiang, Wei Liu, Xiaoming Li, Xianping Xu, Wei |
author_facet | Gong, Lifeng Liu, Xiaowu Yang, Qichao Jiang, Wei Liu, Xiaoming Li, Xianping Xu, Wei |
author_sort | Gong, Lifeng |
collection | PubMed |
description | BACKGROUND: Regarding the thermal ablation treatment of refractory secondary hyperparathyroidism (SHPT), there is no consensus on the ablation range of the hyperplastic parathyroid gland. Therefore, this meta-analysis was conducted to evaluate the efficacy and complications between full and partial thermal ablation in patients with refractory SHPT. METHODS: Databases including PubMed, EMbase, the Cochrane Library, CNKI (China National Knowledge Infrastructure), and Wanfang databases were searched from inception to July 1, 2023. Eligible studies comparing full thermal ablation and partial thermal ablation for SHPT were included. Data were analyzed using Review Manager Version 5.3. RESULTS: Four studies were included in the meta-analysis. Three cohort studies and one randomized controlled trial involving 62 patients in the full thermal ablation group and 63 patients in the partial thermal ablation group were included. The serum parathyroid hormone (PTH), calcium, and phosphorus levels after full ablation were all lower than those after partial ablation (P < .05). There was no significant difference between the partial and full ablation groups concerning the incidence rate of severe hypocalcemia (P = .09). There was no significant difference between the partial and full ablation groups concerning symptom improvement, including bone joint pain, itching, and myasthenia (P < .05). CONCLUSION: Full ablation was superior to partial ablation in terms of reducing PTH, calcium and phosphorus levels. Full ablation might not significantly increase the incidence of severe hypocalcemia. Larger multicentre randomized controlled trials are necessary to confirm the conclusion. |
format | Online Article Text |
id | pubmed-10695584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-106955842023-12-05 Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. Gong, Lifeng Liu, Xiaowu Yang, Qichao Jiang, Wei Liu, Xiaoming Li, Xianping Xu, Wei Medicine (Baltimore) 5200 BACKGROUND: Regarding the thermal ablation treatment of refractory secondary hyperparathyroidism (SHPT), there is no consensus on the ablation range of the hyperplastic parathyroid gland. Therefore, this meta-analysis was conducted to evaluate the efficacy and complications between full and partial thermal ablation in patients with refractory SHPT. METHODS: Databases including PubMed, EMbase, the Cochrane Library, CNKI (China National Knowledge Infrastructure), and Wanfang databases were searched from inception to July 1, 2023. Eligible studies comparing full thermal ablation and partial thermal ablation for SHPT were included. Data were analyzed using Review Manager Version 5.3. RESULTS: Four studies were included in the meta-analysis. Three cohort studies and one randomized controlled trial involving 62 patients in the full thermal ablation group and 63 patients in the partial thermal ablation group were included. The serum parathyroid hormone (PTH), calcium, and phosphorus levels after full ablation were all lower than those after partial ablation (P < .05). There was no significant difference between the partial and full ablation groups concerning the incidence rate of severe hypocalcemia (P = .09). There was no significant difference between the partial and full ablation groups concerning symptom improvement, including bone joint pain, itching, and myasthenia (P < .05). CONCLUSION: Full ablation was superior to partial ablation in terms of reducing PTH, calcium and phosphorus levels. Full ablation might not significantly increase the incidence of severe hypocalcemia. Larger multicentre randomized controlled trials are necessary to confirm the conclusion. Lippincott Williams & Wilkins 2023-12-01 /pmc/articles/PMC10695584/ http://dx.doi.org/10.1097/MD.0000000000036422 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5200 Gong, Lifeng Liu, Xiaowu Yang, Qichao Jiang, Wei Liu, Xiaoming Li, Xianping Xu, Wei Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. |
title | Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. |
title_full | Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. |
title_fullStr | Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. |
title_full_unstemmed | Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. |
title_short | Full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: A meta-analysis. |
title_sort | full thermal ablation versus partial thermal ablation for secondary hyperparathyroidism: a meta-analysis. |
topic | 5200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695584/ http://dx.doi.org/10.1097/MD.0000000000036422 |
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