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Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study
The causal association between circulating β-carotene concentrations and cardiovascular disease (CVD) remains controversial. We conducted a Mendelian randomization study to explore the effects of β-carotene on various cardiovascular diseases, including myocardial infarction, atrial fibrillation, hea...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695590/ http://dx.doi.org/10.1097/MD.0000000000036432 |
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author | Liu, Shuangyan Wu, Qiaoyu Wang, Shangshang He, Ying |
author_facet | Liu, Shuangyan Wu, Qiaoyu Wang, Shangshang He, Ying |
author_sort | Liu, Shuangyan |
collection | PubMed |
description | The causal association between circulating β-carotene concentrations and cardiovascular disease (CVD) remains controversial. We conducted a Mendelian randomization study to explore the effects of β-carotene on various cardiovascular diseases, including myocardial infarction, atrial fibrillation, heart failure, and stroke. Three single nucleotide polymorphisms (SNPs) associated with the β-carotene levels were obtained by searching published data and used as instrumental variables. Genetic association estimates for 4 CVDs (including myocardial infarction, atrial fibrillation, heart failure, and stroke) in the primary analysis, blood pressure and serum lipids (high-density lipoprotein [HDL] cholesterol, LDL cholesterol, and triglycerides) in the secondary analysis were obtained from large-scale genome-wide association studies (GWASs). We applied inverse variance-weighted as the primary analysis method, and 3 others were used to verify as sensitivity analysis. Genetically predicted circulating β-carotene levels (natural log-transformed, µg/L) were positively associated with myocardial infarction (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.02–1.18, P = .011) after Bonferroni correction. No evidence supported the causal effect of β-carotene on atrial fibrillation (OR 1.02, 95% CI 0.96–1.09, P = .464), heart failure (OR 1.07, 95% CI 0.97–1.19, P = .187), stroke (OR 1.03, 95% CI 0.93–1.15, P = .540), blood pressure (P > .372) and serum lipids (P > .239). Sensitivity analysis produced consistent results. This study provides evidence for a causal relationship between circulating β-carotene and myocardial infarction. These findings have important implications for understanding the role of β-carotene in CVD and may inform dietary recommendations and intervention strategies for preventing myocardial infarction. |
format | Online Article Text |
id | pubmed-10695590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-106955902023-12-05 Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study Liu, Shuangyan Wu, Qiaoyu Wang, Shangshang He, Ying Medicine (Baltimore) 3400 The causal association between circulating β-carotene concentrations and cardiovascular disease (CVD) remains controversial. We conducted a Mendelian randomization study to explore the effects of β-carotene on various cardiovascular diseases, including myocardial infarction, atrial fibrillation, heart failure, and stroke. Three single nucleotide polymorphisms (SNPs) associated with the β-carotene levels were obtained by searching published data and used as instrumental variables. Genetic association estimates for 4 CVDs (including myocardial infarction, atrial fibrillation, heart failure, and stroke) in the primary analysis, blood pressure and serum lipids (high-density lipoprotein [HDL] cholesterol, LDL cholesterol, and triglycerides) in the secondary analysis were obtained from large-scale genome-wide association studies (GWASs). We applied inverse variance-weighted as the primary analysis method, and 3 others were used to verify as sensitivity analysis. Genetically predicted circulating β-carotene levels (natural log-transformed, µg/L) were positively associated with myocardial infarction (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.02–1.18, P = .011) after Bonferroni correction. No evidence supported the causal effect of β-carotene on atrial fibrillation (OR 1.02, 95% CI 0.96–1.09, P = .464), heart failure (OR 1.07, 95% CI 0.97–1.19, P = .187), stroke (OR 1.03, 95% CI 0.93–1.15, P = .540), blood pressure (P > .372) and serum lipids (P > .239). Sensitivity analysis produced consistent results. This study provides evidence for a causal relationship between circulating β-carotene and myocardial infarction. These findings have important implications for understanding the role of β-carotene in CVD and may inform dietary recommendations and intervention strategies for preventing myocardial infarction. Lippincott Williams & Wilkins 2023-12-01 /pmc/articles/PMC10695590/ http://dx.doi.org/10.1097/MD.0000000000036432 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 3400 Liu, Shuangyan Wu, Qiaoyu Wang, Shangshang He, Ying Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study |
title | Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study |
title_full | Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study |
title_fullStr | Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study |
title_full_unstemmed | Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study |
title_short | Causal associations between circulation β-carotene and cardiovascular disease: A Mendelian randomization study |
title_sort | causal associations between circulation β-carotene and cardiovascular disease: a mendelian randomization study |
topic | 3400 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695590/ http://dx.doi.org/10.1097/MD.0000000000036432 |
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