Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) controls cell proliferation, differentiation, apoptosis, and other biological processes that have an essential role in eye diseases. However, it seems that previous studies have generated conflicting conclusions about the effect of CaMKII on cel...

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Detalles Bibliográficos
Autores principales: Xu, Weixing, Liu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
5800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695602/
http://dx.doi.org/10.1097/MD.0000000000036136
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author Xu, Weixing
Liu, Hua
author_facet Xu, Weixing
Liu, Hua
author_sort Xu, Weixing
collection PubMed
description Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) controls cell proliferation, differentiation, apoptosis, and other biological processes that have an essential role in eye diseases. However, it seems that previous studies have generated conflicting conclusions about the effect of CaMKII on cell apoptosis. In this review, we explore the positive and potentially deleterious effects of CaMKII on eye cell apoptosis. We can safely conclude that the early elevation of CaMKII could be viewed as a promoter of cell apoptosis. Overexpression of CaMKII by transfection or pretreatment with drugs helped combat cell apoptosis.
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spelling pubmed-106956022023-12-05 Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review Xu, Weixing Liu, Hua Medicine (Baltimore) 5800 Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) controls cell proliferation, differentiation, apoptosis, and other biological processes that have an essential role in eye diseases. However, it seems that previous studies have generated conflicting conclusions about the effect of CaMKII on cell apoptosis. In this review, we explore the positive and potentially deleterious effects of CaMKII on eye cell apoptosis. We can safely conclude that the early elevation of CaMKII could be viewed as a promoter of cell apoptosis. Overexpression of CaMKII by transfection or pretreatment with drugs helped combat cell apoptosis. Lippincott Williams & Wilkins 2023-12-01 /pmc/articles/PMC10695602/ http://dx.doi.org/10.1097/MD.0000000000036136 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5800
Xu, Weixing
Liu, Hua
Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review
title Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review
title_full Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review
title_fullStr Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review
title_full_unstemmed Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review
title_short Is CaMKII friend or foe for cell apoptosis in eye?: A narrative review
title_sort is camkii friend or foe for cell apoptosis in eye?: a narrative review
topic 5800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695602/
http://dx.doi.org/10.1097/MD.0000000000036136
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