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A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea
BACKGROUND: Several cases of pediatric acute hepatitis of unknown etiology related to adenoviral infections have been reported in Europe since January 2022. The aim of this study was to compare the incidence, severity, possible etiology, and prognosis of the disease with those in the past in Korea....
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695753/ http://dx.doi.org/10.3346/jkms.2023.38.e401 |
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author | Lee, Kyung Jae Ko, Jae Sung Park, Kie Young Kang, Ki Soo Lee, Kunsong Hong, Jeana Kim, Soon Chul Lee, Yoon Kang, Ben Kim, Yu Bin Kim, Hyun Jin Eun, Byung Wook Cho, Hye-Kyung Kim, Yae-Jean Kim, Mi Jin Lee, Jin Lee, Taek-Jin Oh, Seak Hee Park, Sowon Hwang, Eun Ha Sohn, Sangjun Lim, Jin Gyu Kim, YooJin Lee, Yeoun Joo |
author_facet | Lee, Kyung Jae Ko, Jae Sung Park, Kie Young Kang, Ki Soo Lee, Kunsong Hong, Jeana Kim, Soon Chul Lee, Yoon Kang, Ben Kim, Yu Bin Kim, Hyun Jin Eun, Byung Wook Cho, Hye-Kyung Kim, Yae-Jean Kim, Mi Jin Lee, Jin Lee, Taek-Jin Oh, Seak Hee Park, Sowon Hwang, Eun Ha Sohn, Sangjun Lim, Jin Gyu Kim, YooJin Lee, Yeoun Joo |
author_sort | Lee, Kyung Jae |
collection | PubMed |
description | BACKGROUND: Several cases of pediatric acute hepatitis of unknown etiology related to adenoviral infections have been reported in Europe since January 2022. The aim of this study was to compare the incidence, severity, possible etiology, and prognosis of the disease with those in the past in Korea. METHODS: The surveillance group collected data between May and November 2022 using a surveillance system. Acute hepatitis of unknown etiology was defined in patients aged < 16 years with a serum transaminase level > 500 IU/L, not due to hepatitis A-E or other underlying causes. For comparison, data from 18 university hospitals were retrospectively collected as a control group between January 2021 and April 2022. RESULTS: We enrolled 270 patients (mean age, 5 years). The most common symptom was fever. However, the incidence was similar between 2021 and 2022. Liver function test results, number of patients with acute liver failure (ALF), liver transplantation (LT), death, and adenovirus detection rates did not differ between the two groups. None of the adenovirus-positive patients in either group experienced ALF, LT, or death. In the surveillance group, adenovirus-associated virus-2 was detected in four patients, one of whom underwent LT. Patients with an unknown etiology showed significantly higher bilirubin levels, a lower platelet count, and a higher LT rate than patients with a possible etiology. CONCLUSION: The incidence of pediatric acute hepatitis of unknown etiology and adenovirus detection rate have not increased in Korea. |
format | Online Article Text |
id | pubmed-10695753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-106957532023-12-06 A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea Lee, Kyung Jae Ko, Jae Sung Park, Kie Young Kang, Ki Soo Lee, Kunsong Hong, Jeana Kim, Soon Chul Lee, Yoon Kang, Ben Kim, Yu Bin Kim, Hyun Jin Eun, Byung Wook Cho, Hye-Kyung Kim, Yae-Jean Kim, Mi Jin Lee, Jin Lee, Taek-Jin Oh, Seak Hee Park, Sowon Hwang, Eun Ha Sohn, Sangjun Lim, Jin Gyu Kim, YooJin Lee, Yeoun Joo J Korean Med Sci Original Article BACKGROUND: Several cases of pediatric acute hepatitis of unknown etiology related to adenoviral infections have been reported in Europe since January 2022. The aim of this study was to compare the incidence, severity, possible etiology, and prognosis of the disease with those in the past in Korea. METHODS: The surveillance group collected data between May and November 2022 using a surveillance system. Acute hepatitis of unknown etiology was defined in patients aged < 16 years with a serum transaminase level > 500 IU/L, not due to hepatitis A-E or other underlying causes. For comparison, data from 18 university hospitals were retrospectively collected as a control group between January 2021 and April 2022. RESULTS: We enrolled 270 patients (mean age, 5 years). The most common symptom was fever. However, the incidence was similar between 2021 and 2022. Liver function test results, number of patients with acute liver failure (ALF), liver transplantation (LT), death, and adenovirus detection rates did not differ between the two groups. None of the adenovirus-positive patients in either group experienced ALF, LT, or death. In the surveillance group, adenovirus-associated virus-2 was detected in four patients, one of whom underwent LT. Patients with an unknown etiology showed significantly higher bilirubin levels, a lower platelet count, and a higher LT rate than patients with a possible etiology. CONCLUSION: The incidence of pediatric acute hepatitis of unknown etiology and adenovirus detection rate have not increased in Korea. The Korean Academy of Medical Sciences 2023-11-22 /pmc/articles/PMC10695753/ http://dx.doi.org/10.3346/jkms.2023.38.e401 Text en © 2023 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Kyung Jae Ko, Jae Sung Park, Kie Young Kang, Ki Soo Lee, Kunsong Hong, Jeana Kim, Soon Chul Lee, Yoon Kang, Ben Kim, Yu Bin Kim, Hyun Jin Eun, Byung Wook Cho, Hye-Kyung Kim, Yae-Jean Kim, Mi Jin Lee, Jin Lee, Taek-Jin Oh, Seak Hee Park, Sowon Hwang, Eun Ha Sohn, Sangjun Lim, Jin Gyu Kim, YooJin Lee, Yeoun Joo A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea |
title | A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea |
title_full | A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea |
title_fullStr | A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea |
title_full_unstemmed | A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea |
title_short | A Report on a Nationwide Surveillance System for Pediatric Acute Hepatitis of Unknown Etiology in Korea |
title_sort | report on a nationwide surveillance system for pediatric acute hepatitis of unknown etiology in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695753/ http://dx.doi.org/10.3346/jkms.2023.38.e401 |
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