A biotin targeting chimera (BioTAC) system to map small molecule interactomes in situ

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Understanding how small molecules bind to specific protein complexes in living cells is critical to understanding their mechanism-of-action. Unbiased chemical biology strategies for direct readout of protein interactome remodelling by small molecules would provide advantages over target-focused appr...

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Detalles Bibliográficos
Autores principales: Tao, Andrew J., Jiang, Jiewei, Gadbois, Gillian E., Goyal, Pavitra, Boyle, Bridget T., Mumby, Elizabeth J., Myers, Samuel A., English, Justin G., Ferguson, Fleur M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10695998/
https://www.ncbi.nlm.nih.gov/pubmed/38049406
http://dx.doi.org/10.1038/s41467-023-43507-5

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