Toxoplasma rhoptry proteins that affect encephalitis outcome

Toxoplasma gondii, a widespread obligate intracellular parasite, can infect almost all warm-blooded animals, including humans. The cellular barrier of the central nervous system (CNS) is generally able to protect the brain parenchyma from infectious damage. However, T. gondii typically causes latent...

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Autores principales: Wang, Xinlei, Qu, Lai, Chen, Jie, Jin, Yufen, Hu, Kaisong, Zhou, Zhengjie, Zhang, Jiaqi, An, Yiming, Zheng, Jingtong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696021/
https://www.ncbi.nlm.nih.gov/pubmed/38049394
http://dx.doi.org/10.1038/s41420-023-01742-1
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author Wang, Xinlei
Qu, Lai
Chen, Jie
Jin, Yufen
Hu, Kaisong
Zhou, Zhengjie
Zhang, Jiaqi
An, Yiming
Zheng, Jingtong
author_facet Wang, Xinlei
Qu, Lai
Chen, Jie
Jin, Yufen
Hu, Kaisong
Zhou, Zhengjie
Zhang, Jiaqi
An, Yiming
Zheng, Jingtong
author_sort Wang, Xinlei
collection PubMed
description Toxoplasma gondii, a widespread obligate intracellular parasite, can infect almost all warm-blooded animals, including humans. The cellular barrier of the central nervous system (CNS) is generally able to protect the brain parenchyma from infectious damage. However, T. gondii typically causes latent brain infections in humans and other vertebrates. Here, we discuss how T. gondii rhoptry proteins (ROPs) affect signaling pathways in host cells and speculate how this might affect the outcome of Toxoplasma encephalitis.
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spelling pubmed-106960212023-12-06 Toxoplasma rhoptry proteins that affect encephalitis outcome Wang, Xinlei Qu, Lai Chen, Jie Jin, Yufen Hu, Kaisong Zhou, Zhengjie Zhang, Jiaqi An, Yiming Zheng, Jingtong Cell Death Discov Review Article Toxoplasma gondii, a widespread obligate intracellular parasite, can infect almost all warm-blooded animals, including humans. The cellular barrier of the central nervous system (CNS) is generally able to protect the brain parenchyma from infectious damage. However, T. gondii typically causes latent brain infections in humans and other vertebrates. Here, we discuss how T. gondii rhoptry proteins (ROPs) affect signaling pathways in host cells and speculate how this might affect the outcome of Toxoplasma encephalitis. Nature Publishing Group UK 2023-12-04 /pmc/articles/PMC10696021/ /pubmed/38049394 http://dx.doi.org/10.1038/s41420-023-01742-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Wang, Xinlei
Qu, Lai
Chen, Jie
Jin, Yufen
Hu, Kaisong
Zhou, Zhengjie
Zhang, Jiaqi
An, Yiming
Zheng, Jingtong
Toxoplasma rhoptry proteins that affect encephalitis outcome
title Toxoplasma rhoptry proteins that affect encephalitis outcome
title_full Toxoplasma rhoptry proteins that affect encephalitis outcome
title_fullStr Toxoplasma rhoptry proteins that affect encephalitis outcome
title_full_unstemmed Toxoplasma rhoptry proteins that affect encephalitis outcome
title_short Toxoplasma rhoptry proteins that affect encephalitis outcome
title_sort toxoplasma rhoptry proteins that affect encephalitis outcome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696021/
https://www.ncbi.nlm.nih.gov/pubmed/38049394
http://dx.doi.org/10.1038/s41420-023-01742-1
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