JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of Alzheimer’s disease (AD). Mobilization of transposable elements (TEs) in heterochromatic regions was recently reported in AD, but the underlying mechanisms are still underappreciated. Combining functional genom...

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Detalles Bibliográficos
Autores principales: Scopa, Chiara, Barnada, Samantha M., Cicardi, Maria E., Singer, Mo, Trotti, Davide, Trizzino, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696058/
https://www.ncbi.nlm.nih.gov/pubmed/38049398
http://dx.doi.org/10.1038/s41467-023-43728-8

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