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Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%–85% of total cases and leading to millions of deaths worldwide. Drug resistance is the primary cause of treatment failure in NSCLC, which urges scientists to develop advanced approaches for NSCLC treatment....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696070/ http://dx.doi.org/10.1016/j.heliyon.2023.e22080 |
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author | Le, Mai Thi Nguyen, Huyen-Thu Nguyen, Xuan-Hung Do, Xuan-Hai Mai, Binh Thanh Ngoc Nguyen, Ha Thi Trang Than, Uyen Thi Nguyen, Thanh-Hong |
author_facet | Le, Mai Thi Nguyen, Huyen-Thu Nguyen, Xuan-Hung Do, Xuan-Hai Mai, Binh Thanh Ngoc Nguyen, Ha Thi Trang Than, Uyen Thi Nguyen, Thanh-Hong |
author_sort | Le, Mai Thi |
collection | PubMed |
description | Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%–85% of total cases and leading to millions of deaths worldwide. Drug resistance is the primary cause of treatment failure in NSCLC, which urges scientists to develop advanced approaches for NSCLC treatment. Among novel approaches, the miRNA-based method has emerged as a potential approach as it allows researchers to modulate target gene expression. Subsequently, cell behaviors are altered, which leads to the death and the depletion of cancer cells. It has been reported that miRNAs possess the capacity to regulate multiple genes that are involved in various signaling pathways, including the phosphoinositide 3-kinase, receptor tyrosine kinase/rat sarcoma virus/mitogen-activated protein kinase, wingless/integrated, retinoblastoma, p53, transforming growth factor β, and nuclear factor-kappa B pathways. Dysregulation of these signaling pathways in NSCLC results in abnormal cell proliferation, tissue invasion, and drug resistance while inhibiting apoptosis. Thus, understanding the roles of miRNAs in regulating these signaling pathways may enable the development of novel NSCLC treatment therapies. However, a comprehensive review of potential miRNAs in NSCLC treatment has been lacking. Therefore, this review aims to fill the gap by summarizing the up-to-date information on miRNAs regarding their targets, impact on cancer-associated pathways, and prospective outcomes in treating NSCLC. We also discuss current technologies for delivering miRNAs to the target cells, including virus-based, non-viral, and emerging extracellular vesicle-based delivery systems. This knowledge will support future studies to develop an innovative miRNA-based therapy and select a suitable carrier to treat NSCLC effectively. |
format | Online Article Text |
id | pubmed-10696070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-106960702023-12-06 Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer Le, Mai Thi Nguyen, Huyen-Thu Nguyen, Xuan-Hung Do, Xuan-Hai Mai, Binh Thanh Ngoc Nguyen, Ha Thi Trang Than, Uyen Thi Nguyen, Thanh-Hong Heliyon Review Article Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80%–85% of total cases and leading to millions of deaths worldwide. Drug resistance is the primary cause of treatment failure in NSCLC, which urges scientists to develop advanced approaches for NSCLC treatment. Among novel approaches, the miRNA-based method has emerged as a potential approach as it allows researchers to modulate target gene expression. Subsequently, cell behaviors are altered, which leads to the death and the depletion of cancer cells. It has been reported that miRNAs possess the capacity to regulate multiple genes that are involved in various signaling pathways, including the phosphoinositide 3-kinase, receptor tyrosine kinase/rat sarcoma virus/mitogen-activated protein kinase, wingless/integrated, retinoblastoma, p53, transforming growth factor β, and nuclear factor-kappa B pathways. Dysregulation of these signaling pathways in NSCLC results in abnormal cell proliferation, tissue invasion, and drug resistance while inhibiting apoptosis. Thus, understanding the roles of miRNAs in regulating these signaling pathways may enable the development of novel NSCLC treatment therapies. However, a comprehensive review of potential miRNAs in NSCLC treatment has been lacking. Therefore, this review aims to fill the gap by summarizing the up-to-date information on miRNAs regarding their targets, impact on cancer-associated pathways, and prospective outcomes in treating NSCLC. We also discuss current technologies for delivering miRNAs to the target cells, including virus-based, non-viral, and emerging extracellular vesicle-based delivery systems. This knowledge will support future studies to develop an innovative miRNA-based therapy and select a suitable carrier to treat NSCLC effectively. Elsevier 2023-11-14 /pmc/articles/PMC10696070/ http://dx.doi.org/10.1016/j.heliyon.2023.e22080 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Le, Mai Thi Nguyen, Huyen-Thu Nguyen, Xuan-Hung Do, Xuan-Hai Mai, Binh Thanh Ngoc Nguyen, Ha Thi Trang Than, Uyen Thi Nguyen, Thanh-Hong Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
title | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
title_full | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
title_fullStr | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
title_full_unstemmed | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
title_short | Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer |
title_sort | regulation and therapeutic potentials of micrornas to non-small cell lung cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696070/ http://dx.doi.org/10.1016/j.heliyon.2023.e22080 |
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