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Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI
To analyze cerebral arteriovenous pulse propagation and to generate phase-resolved pulse amplitude maps from a fast gradient-echo sequence offering flow-related enhancement (FREE). Brain MRI was performed using a balanced steady-state free precession sequence at 3T followed by retrospective k-space...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696084/ https://www.ncbi.nlm.nih.gov/pubmed/38049511 http://dx.doi.org/10.1038/s41598-023-48439-0 |
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author | Kornemann, Norman Klimeš, Filip Kern, Agilo Luitger Behrendt, Lea Voskrebenzev, Andreas Gutberlet, Marcel Wattjes, Mike P. Wacker, Frank Vogel-Claussen, Jens Glandorf, Julian |
author_facet | Kornemann, Norman Klimeš, Filip Kern, Agilo Luitger Behrendt, Lea Voskrebenzev, Andreas Gutberlet, Marcel Wattjes, Mike P. Wacker, Frank Vogel-Claussen, Jens Glandorf, Julian |
author_sort | Kornemann, Norman |
collection | PubMed |
description | To analyze cerebral arteriovenous pulse propagation and to generate phase-resolved pulse amplitude maps from a fast gradient-echo sequence offering flow-related enhancement (FREE). Brain MRI was performed using a balanced steady-state free precession sequence at 3T followed by retrospective k-space gating. The time interval of the pulse wave between anterior-, middle- and posterior cerebral artery territories and the superior sagittal sinus were calculated and compared between and older and younger groups within 24 healthy volunteers. Pulse amplitude maps were generated and compared to pseudo-Continuous Arterial Spin Labeling (pCASL) MRI maps by voxel-wise Pearson correlation, Sørensen-Dice maps and in regards to signal contrast. The arteriovenous delays between all vascular territories and the superior sagittal sinus were significantly shorter in the older age group (11 individuals, ≥ 31 years) ranging between 169 ± 112 and 246 ± 299 ms versus 286 ± 244 to 419 ± 299 ms in the younger age group (13 individuals) (P ≤ 0.04). The voxel-wise pulse wave amplitude values and perfusion-weighted pCASL values correlated significantly (Pearson-r = 0.33, P < 0.01). Mean Dice overlaps of high (gray) and low (white matter) regions were 73 ± 3% and 59 ± 5%. No differences in image contrast were seen in the whole brain and the white matter, but significantly higher mean contrast of 0.73 ± 0.23% in cortical gray matter in FREE-MRI compared to 0.52 ± 0.12% in pCASL-MRI (P = 0.01). The dynamic information of flow-related enhancement allows analysis of the cerebral pulse wave propagation potentially providing information about the (micro)circulation on a regional level. However, the pulse wave amplitude reveals weaknesses in comparison to true perfusion-weighting and could rather be used to calculate a pulsatility index. |
format | Online Article Text |
id | pubmed-10696084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106960842023-12-06 Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI Kornemann, Norman Klimeš, Filip Kern, Agilo Luitger Behrendt, Lea Voskrebenzev, Andreas Gutberlet, Marcel Wattjes, Mike P. Wacker, Frank Vogel-Claussen, Jens Glandorf, Julian Sci Rep Article To analyze cerebral arteriovenous pulse propagation and to generate phase-resolved pulse amplitude maps from a fast gradient-echo sequence offering flow-related enhancement (FREE). Brain MRI was performed using a balanced steady-state free precession sequence at 3T followed by retrospective k-space gating. The time interval of the pulse wave between anterior-, middle- and posterior cerebral artery territories and the superior sagittal sinus were calculated and compared between and older and younger groups within 24 healthy volunteers. Pulse amplitude maps were generated and compared to pseudo-Continuous Arterial Spin Labeling (pCASL) MRI maps by voxel-wise Pearson correlation, Sørensen-Dice maps and in regards to signal contrast. The arteriovenous delays between all vascular territories and the superior sagittal sinus were significantly shorter in the older age group (11 individuals, ≥ 31 years) ranging between 169 ± 112 and 246 ± 299 ms versus 286 ± 244 to 419 ± 299 ms in the younger age group (13 individuals) (P ≤ 0.04). The voxel-wise pulse wave amplitude values and perfusion-weighted pCASL values correlated significantly (Pearson-r = 0.33, P < 0.01). Mean Dice overlaps of high (gray) and low (white matter) regions were 73 ± 3% and 59 ± 5%. No differences in image contrast were seen in the whole brain and the white matter, but significantly higher mean contrast of 0.73 ± 0.23% in cortical gray matter in FREE-MRI compared to 0.52 ± 0.12% in pCASL-MRI (P = 0.01). The dynamic information of flow-related enhancement allows analysis of the cerebral pulse wave propagation potentially providing information about the (micro)circulation on a regional level. However, the pulse wave amplitude reveals weaknesses in comparison to true perfusion-weighting and could rather be used to calculate a pulsatility index. Nature Publishing Group UK 2023-12-04 /pmc/articles/PMC10696084/ /pubmed/38049511 http://dx.doi.org/10.1038/s41598-023-48439-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kornemann, Norman Klimeš, Filip Kern, Agilo Luitger Behrendt, Lea Voskrebenzev, Andreas Gutberlet, Marcel Wattjes, Mike P. Wacker, Frank Vogel-Claussen, Jens Glandorf, Julian Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI |
title | Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI |
title_full | Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI |
title_fullStr | Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI |
title_full_unstemmed | Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI |
title_short | Cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated MRI |
title_sort | cerebral microcirculatory pulse wave propagation and pulse wave amplitude mapping in retrospectively gated mri |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696084/ https://www.ncbi.nlm.nih.gov/pubmed/38049511 http://dx.doi.org/10.1038/s41598-023-48439-0 |
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