The molecular basis of dapsone activation of CYP2C9-catalyzed nonsteroidal anti-inflammatory drug oxidation

Positive heterotropic cooperativity, or “activation,” results in an instantaneous increase in enzyme activity in the absence of an increase in protein expression. Thus, cytochrome P450 (CYP) enzyme activation presents as a potential drug–drug interaction mechanism. It has been demonstrated previousl...

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Detalles Bibliográficos
Autores principales: Nair, Pramod C., Burns, Kushari, Chau, Nuy, McKinnon, Ross A., Miners, John O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696402/
http://dx.doi.org/10.1016/j.jbc.2023.105368

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