Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions

Sterile 20–like kinases Mst1 and Mst2 (Mst1/2) and large tumor suppressor 1/2 are core kinases to mediate Hippo signaling in maintaining tissue homeostasis. We have previously demonstrated that Smad ubiquitin (Ub) regulatory factor 1 (Smurf1), a HECT-type E3 ligase, ubiquitinates and in turn destabi...

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Detalles Bibliográficos
Autores principales: Xu, Yana, Qu, Meiyu, He, Yangxun, He, Qiangqiang, Shen, Tingyu, Luo, Jiahao, Tan, Dan, Bao, Hangyang, Xu, Chengyun, Ji, Xing, Hu, Xinhua, Barkat, Muhammad Qasim, Zeng, Ling-Hui, Wu, Ximei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696403/
http://dx.doi.org/10.1016/j.jbc.2023.105395

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