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New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants

The extracellular region of the complement receptor of the Ig superfamily (CRIg) binds to certain C3 cleavage products (C3b, iC3b, C3c) and inhibits the alternative pathway (AP) of complement. In this study, we provide further insight into the CRIg protein and describe two CRIg mutants that lack mul...

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Detalles Bibliográficos
Autores principales:	Duan, Huiquan, Abram, Troy G., Cruz, Ana Rita, Rooijakkers, Suzan H. M., Geisbrecht, Brian V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AAI 2023
Materias:	Innate Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696418/ https://www.ncbi.nlm.nih.gov/pubmed/38032267 http://dx.doi.org/10.4049/immunohorizons.2300064

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