Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

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Phase separation compartmentalizes many cellular pathways. Given that the same interactions that drive phase separation mediate the formation of soluble complexes below the saturation concentration, the contribution of condensates versus complexes to function is sometimes unclear. Here, we character...

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Detalles Bibliográficos
Autores principales: Sabri, Nafiseh, Cuneo, Matthew J., Marzahn, Melissa R., Lee, Jihun, Bouchard, Jill J., Güllülü, Ömer, Vaithiyalingam, Sivaraja, Borgia, Madeleine B., Schmit, Jeremy, Mittag, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696467/
http://dx.doi.org/10.1016/j.jbc.2023.105427

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