Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations

This paper reports the case of a 27-year-old man with paranoid schizophrenia who was finally stabilized on clozapine medication. After vaccination against severe acute respiratory syndrome coronavirus 2, serum levels of clozapine increased. It is well established that immune responses can trigger cy...

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Detalles Bibliográficos
Autores principales: Kersting, Xenia A. K., Momtahen, Nicoletta, Lieb, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696469/
http://dx.doi.org/10.1155/2023/9914879
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author Kersting, Xenia A. K.
Momtahen, Nicoletta
Lieb, Klaus
author_facet Kersting, Xenia A. K.
Momtahen, Nicoletta
Lieb, Klaus
author_sort Kersting, Xenia A. K.
collection PubMed
description This paper reports the case of a 27-year-old man with paranoid schizophrenia who was finally stabilized on clozapine medication. After vaccination against severe acute respiratory syndrome coronavirus 2, serum levels of clozapine increased. It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication.
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spelling pubmed-106964692023-12-06 Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations Kersting, Xenia A. K. Momtahen, Nicoletta Lieb, Klaus Case Rep Psychiatry Case Report This paper reports the case of a 27-year-old man with paranoid schizophrenia who was finally stabilized on clozapine medication. After vaccination against severe acute respiratory syndrome coronavirus 2, serum levels of clozapine increased. It is well established that immune responses can trigger cytokine cascades affecting drug metabolism, which, in the case of clozapine treatment, can lead to severe intoxication. Hindawi 2023-11-27 /pmc/articles/PMC10696469/ http://dx.doi.org/10.1155/2023/9914879 Text en Copyright © 2023 Xenia A. K. Kersting et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kersting, Xenia A. K.
Momtahen, Nicoletta
Lieb, Klaus
Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
title Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
title_full Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
title_fullStr Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
title_full_unstemmed Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
title_short Clozapine Serum Concentrations Are Disrupted by SARS-CoV-2 Vaccinations
title_sort clozapine serum concentrations are disrupted by sars-cov-2 vaccinations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696469/
http://dx.doi.org/10.1155/2023/9914879
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AT liebklaus clozapineserumconcentrationsaredisruptedbysarscov2vaccinations

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