Cargando…

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

IMPORTANCE: Nonmotor symptoms of Parkinson disease (PD) often predate the movement disorder by decades. Currently, there is no blood biomarker to define this prodromal phase. OBJECTIVE: To investigate whether α-synuclein in neuronally derived serum-extracellular vesicles identifies individuals at ri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Shijun, Jiang, Cheng, Janzen, Annette, Barber, Thomas R., Seger, Aline, Sommerauer, Michael, Davis, Jason J., Marek, Kenneth, Hu, Michele T., Oertel, Wolfgang H., Tofaris, George K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2023
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696516/ https://www.ncbi.nlm.nih.gov/pubmed/38048087 http://dx.doi.org/10.1001/jamaneurol.2023.4398

Ejemplares similares

Methodological considerations in neuronal extracellular vesicle isolation for α-synuclein biomarkers
por: Yan, Shijun, et al.
Publicado: (2023)

Initiation and progression of α-synuclein pathology in Parkinson’s disease
por: Tofaris, George K.
Publicado: (2022)

Plasma Extracellular Vesicle α-Synuclein Level in Patients with Parkinson’s Disease
por: Chung, Chen-Chih, et al.
Publicado: (2021)

α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
por: Wang, Pan, et al.
Publicado: (2023)

Alternating Magnetic Field-Promoted Nanoparticle Mixing: The On-Chip Immunocapture of Serum Neuronal Exosomes for Parkinson’s Disease Diagnostics
por: Sharafeldin, Mohamed, et al.
Publicado: (2023)

Multiplexed Profiling of Extracellular Vesicles for Biomarker Development
por: Jiang, Cheng, et al.
Publicado: (2021)

The roles of connectivity and neuronal phenotype in determining the pattern of α-synuclein pathology in Parkinson's disease
por: Henderson, Michael X., et al.
Publicado: (2022)

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
por: Fernandes, Hugo J.R., et al.
Publicado: (2016)

Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson’s disease
por: Doppler, Kathrin, et al.
Publicado: (2017)

α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson’s disease
por: Liu, Zongran, et al.
Publicado: (2022)

Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson’s Disease Diagnostics
por: Fu, Ying, et al.
Publicado: (2020)

Neuroprotektive Therapien bei idiopathischen, genetischen und atypischen Parkinson-Syndromen mit α-Synuklein – Pathologie
por: Levin, Johannes, et al.
Publicado: (2021)

Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons
por: Tanudjojo, Benedict, et al.
Publicado: (2021)

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
por: Kunadt, Marcel, et al.
Publicado: (2015)

Poly (ADP-Ribose) and α–synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity
por: Lucien, Fabrice, et al.
Publicado: (2022)

A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia
por: Henrich, Martin Timo, et al.
Publicado: (2018)

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease
por: Wang, Zerui, et al.
Publicado: (2020)

Dermal Phospho-Alpha-Synuclein Deposition in Patients With Parkinson's Disease and Mutation of the Glucocerebrosidase Gene
por: Doppler, Kathrin, et al.
Publicado: (2018)

Plasma extracellular vesicle tau, β-amyloid, and α-synuclein and the progression of Parkinson’s disease: a follow-up study
por: Chan, Lung, et al.
Publicado: (2023)

Longitudinal Analyses of Cerebrospinal Fluid α-Synuclein in Prodromal and Early Parkinson’s Disease
por: Mollenhauer, Brit, et al.
Publicado: (2019)

Extracellular α-synuclein levels are regulated by neuronal activity
por: Yamada, Kaoru, et al.
Publicado: (2018)

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells
por: Gustafsson, Gabriel, et al.
Publicado: (2018)

Validation of α‐Synuclein in L1CAM‐Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes
por: Jiang, Cheng, et al.
Publicado: (2021)

Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism
por: Jiang, Cheng, et al.
Publicado: (2020)

Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease
por: Leggio, Loredana, et al.
Publicado: (2020)

Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
por: Schaffrath, Anja, et al.
Publicado: (2023)

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
por: Dening, Yanina, et al.
Publicado: (2022)

Glia-Derived Extracellular Vesicles in Parkinson’s Disease
por: Marchetti, Bianca, et al.
Publicado: (2020)

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease
por: Upadhya, Raghavendra, et al.
Publicado: (2021)

Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles
por: Agliardi, Cristina, et al.
Publicado: (2021)

An intact membrane is essential for small extracellular vesicle‐induced modulation of α‐synuclein fibrillization
por: Ugalde, Cathryn L., et al.
Publicado: (2020)

Occipital hypometabolism is a risk factor for conversion to Parkinson’s disease in isolated REM sleep behaviour disorder
por: Carli, Giulia, et al.
Publicado: (2023)

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons
por: Ganjam, Goutham K., et al.
Publicado: (2019)

The contribution of alpha synuclein to neuronal survival and function – Implications for Parkinson's disease
por: Benskey, Matthew J., et al.
Publicado: (2016)

A Critical Assessment of Exosomes in the Pathogenesis and Stratification of Parkinson’s Disease
por: Tofaris, George K.
Publicado: (2017)

A minute fraction of α-synuclein in extracellular vesicles may be a major contributor to α-synuclein spreading following autophagy inhibition
por: Taha, Hash Brown, et al.
Publicado: (2022)

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease
por: Davies, Sian E., et al.
Publicado: (2014)

Extracellular vesicle markers in relation to obesity and metabolic complications in patients with manifest cardiovascular disease
por: Kranendonk, Mariëtte EG, et al.
Publicado: (2014)

Propagation of Parkinson's disease by extracellular vesicle production and secretion
por: Shippey, Laura E., et al.
Publicado: (2022)

Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord
por: Izco, Maria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vtcerp9fk0d4a0piobjicjd3ak