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Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals
[Image: see text] Probiotics are live microorganisms that confer health benefits when administered in adequate amounts. They are used to promote gut health and alleviate various disorders. Recently, there has been an increasing interest in the potential effects of probiotics on human physiology. In...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696601/ https://www.ncbi.nlm.nih.gov/pubmed/37970754 http://dx.doi.org/10.1021/acs.jproteome.3c00548 |
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author | Di Cesare, Francesca Calgaro, Matteo Ghini, Veronica Squarzanti, Diletta Francesca De Prisco, Annachiara Visciglia, Annalisa Zanetta, Paola Rolla, Roberta Savoia, Paola Amoruso, Angela Azzimonti, Barbara Vitulo, Nicola Tenori, Leonardo Luchinat, Claudio Pane, Marco |
author_facet | Di Cesare, Francesca Calgaro, Matteo Ghini, Veronica Squarzanti, Diletta Francesca De Prisco, Annachiara Visciglia, Annalisa Zanetta, Paola Rolla, Roberta Savoia, Paola Amoruso, Angela Azzimonti, Barbara Vitulo, Nicola Tenori, Leonardo Luchinat, Claudio Pane, Marco |
author_sort | Di Cesare, Francesca |
collection | PubMed |
description | [Image: see text] Probiotics are live microorganisms that confer health benefits when administered in adequate amounts. They are used to promote gut health and alleviate various disorders. Recently, there has been an increasing interest in the potential effects of probiotics on human physiology. In the presented study, the effects of probiotic treatment on the metabolic profiles of human urine and serum using a nuclear magnetic resonance (NMR)-based metabonomic approach were investigated. Twenty-one healthy volunteers were enrolled in the study, and they received two different dosages of probiotics for 8 weeks. During the study, urine and serum samples were collected from volunteers before and during probiotic supplementation. The results showed that probiotics had a significant impact on the urinary and serum metabolic profiles without altering their phenotypes. This study demonstrated the effects of probiotics in terms of variations of metabolite levels resulting also from the different probiotic posology. Overall, the results suggest that probiotic administration may affect both urine and serum metabolomes, although more research is needed to understand the mechanisms and clinical implications of these effects. NMR-based metabonomic analysis of biofluids is a powerful tool for monitoring host-gut microflora dynamic interaction as well as for assessing the individual response to probiotic treatment. |
format | Online Article Text |
id | pubmed-10696601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-106966012023-12-06 Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals Di Cesare, Francesca Calgaro, Matteo Ghini, Veronica Squarzanti, Diletta Francesca De Prisco, Annachiara Visciglia, Annalisa Zanetta, Paola Rolla, Roberta Savoia, Paola Amoruso, Angela Azzimonti, Barbara Vitulo, Nicola Tenori, Leonardo Luchinat, Claudio Pane, Marco J Proteome Res [Image: see text] Probiotics are live microorganisms that confer health benefits when administered in adequate amounts. They are used to promote gut health and alleviate various disorders. Recently, there has been an increasing interest in the potential effects of probiotics on human physiology. In the presented study, the effects of probiotic treatment on the metabolic profiles of human urine and serum using a nuclear magnetic resonance (NMR)-based metabonomic approach were investigated. Twenty-one healthy volunteers were enrolled in the study, and they received two different dosages of probiotics for 8 weeks. During the study, urine and serum samples were collected from volunteers before and during probiotic supplementation. The results showed that probiotics had a significant impact on the urinary and serum metabolic profiles without altering their phenotypes. This study demonstrated the effects of probiotics in terms of variations of metabolite levels resulting also from the different probiotic posology. Overall, the results suggest that probiotic administration may affect both urine and serum metabolomes, although more research is needed to understand the mechanisms and clinical implications of these effects. NMR-based metabonomic analysis of biofluids is a powerful tool for monitoring host-gut microflora dynamic interaction as well as for assessing the individual response to probiotic treatment. American Chemical Society 2023-11-16 /pmc/articles/PMC10696601/ /pubmed/37970754 http://dx.doi.org/10.1021/acs.jproteome.3c00548 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Di Cesare, Francesca Calgaro, Matteo Ghini, Veronica Squarzanti, Diletta Francesca De Prisco, Annachiara Visciglia, Annalisa Zanetta, Paola Rolla, Roberta Savoia, Paola Amoruso, Angela Azzimonti, Barbara Vitulo, Nicola Tenori, Leonardo Luchinat, Claudio Pane, Marco Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals |
title | Exploring
the
Effects of Probiotic Treatment on Urinary
and Serum Metabolic Profiles in Healthy Individuals |
title_full | Exploring
the
Effects of Probiotic Treatment on Urinary
and Serum Metabolic Profiles in Healthy Individuals |
title_fullStr | Exploring
the
Effects of Probiotic Treatment on Urinary
and Serum Metabolic Profiles in Healthy Individuals |
title_full_unstemmed | Exploring
the
Effects of Probiotic Treatment on Urinary
and Serum Metabolic Profiles in Healthy Individuals |
title_short | Exploring
the
Effects of Probiotic Treatment on Urinary
and Serum Metabolic Profiles in Healthy Individuals |
title_sort | exploring
the
effects of probiotic treatment on urinary
and serum metabolic profiles in healthy individuals |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696601/ https://www.ncbi.nlm.nih.gov/pubmed/37970754 http://dx.doi.org/10.1021/acs.jproteome.3c00548 |
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