Is It Always Unethical to Use a Placebo in a Clinical Trial?

Background to the debate: Placebos are used in trials to conceal whether a treatment is being given or not and hence to control for the psychosomatic effects of offering treatment. Placebo-controlled trials are controversial. Critics of such trials argue that if a proven effective therapy exists, a...

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Autores principales: Stang, Andreas, Hense, Hans-Werner, Jöckel, Karl-Heinz, Turner, Erick H, Tramèr, Martin R
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
The PLoS Medicine Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069666/
https://www.ncbi.nlm.nih.gov/pubmed/15783259
http://dx.doi.org/10.1371/journal.pmed.0020072
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author Stang, Andreas
Hense, Hans-Werner
Jöckel, Karl-Heinz
Turner, Erick H
Tramèr, Martin R
author_facet Stang, Andreas
Hense, Hans-Werner
Jöckel, Karl-Heinz
Turner, Erick H
Tramèr, Martin R
author_sort Stang, Andreas
collection PubMed
description Background to the debate: Placebos are used in trials to conceal whether a treatment is being given or not and hence to control for the psychosomatic effects of offering treatment. Placebo-controlled trials are controversial. Critics of such trials argue that if a proven effective therapy exists, a placebo should not be used. But proponents argue that placebo trials are still crucial to prove the efficacy and safety of many treatments.
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spelling pubmed-10696662005-03-29 Is It Always Unethical to Use a Placebo in a Clinical Trial? Stang, Andreas Hense, Hans-Werner Jöckel, Karl-Heinz Turner, Erick H Tramèr, Martin R PLoS Med The PLoS Medicine Debate Background to the debate: Placebos are used in trials to conceal whether a treatment is being given or not and hence to control for the psychosomatic effects of offering treatment. Placebo-controlled trials are controversial. Critics of such trials argue that if a proven effective therapy exists, a placebo should not be used. But proponents argue that placebo trials are still crucial to prove the efficacy and safety of many treatments. Public Library of Science 2005-03 2005-03-29 /pmc/articles/PMC1069666/ /pubmed/15783259 http://dx.doi.org/10.1371/journal.pmed.0020072 Text en Copyright: © 2005 Stang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle The PLoS Medicine Debate
Stang, Andreas
Hense, Hans-Werner
Jöckel, Karl-Heinz
Turner, Erick H
Tramèr, Martin R
Is It Always Unethical to Use a Placebo in a Clinical Trial?
title Is It Always Unethical to Use a Placebo in a Clinical Trial?
title_full Is It Always Unethical to Use a Placebo in a Clinical Trial?
title_fullStr Is It Always Unethical to Use a Placebo in a Clinical Trial?
title_full_unstemmed Is It Always Unethical to Use a Placebo in a Clinical Trial?
title_short Is It Always Unethical to Use a Placebo in a Clinical Trial?
title_sort is it always unethical to use a placebo in a clinical trial?
topic The PLoS Medicine Debate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069666/
https://www.ncbi.nlm.nih.gov/pubmed/15783259
http://dx.doi.org/10.1371/journal.pmed.0020072
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