Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes

BACKGROUND: Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change in osteoarthritis, and persistent inflammation is one of the driving factors of cartilage degeneration. Cucurbitacin E, an isolated compound in the Cucurbitacin f...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Xu, Hui, Li, Xin, Chen, Hongwei, Zhang, Haigang, Zhu, Xunpeng, Lin, Zhijie, Guo, Shilei, Bao, Zhibo, Rui, Haicheng, He, Wei, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696753/
https://www.ncbi.nlm.nih.gov/pubmed/38049841
http://dx.doi.org/10.1186/s12967-023-04771-7

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