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Self-assembling biomolecules for biosensor applications

Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In...

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Autores principales: Kim, Ji-eun, Kang, Jeon Hyeong, Kwon, Woo Hyun, Lee, Inseo, Park, Sang Jun, Kim, Chun-Ho, Jeong, Woo-jin, Choi, Jun Shik, Kim, Kyobum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696764/
http://dx.doi.org/10.1186/s40824-023-00466-8
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author Kim, Ji-eun
Kang, Jeon Hyeong
Kwon, Woo Hyun
Lee, Inseo
Park, Sang Jun
Kim, Chun-Ho
Jeong, Woo-jin
Choi, Jun Shik
Kim, Kyobum
author_facet Kim, Ji-eun
Kang, Jeon Hyeong
Kwon, Woo Hyun
Lee, Inseo
Park, Sang Jun
Kim, Chun-Ho
Jeong, Woo-jin
Choi, Jun Shik
Kim, Kyobum
author_sort Kim, Ji-eun
collection PubMed
description Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In addition, the use of supramolecular structure change upon binding is an intriguing approach to generate binding signal. Therefore, many self-assembled nanostructure-based biosensors have been developed over the past decades, using various biomolecules (e.g., peptides, DNA, RNA, lipids) and their combinations with non-biological substances. In this review, we provide an overview of recent developments in the design and fabrication of self-assembling biomolecules for biosensing. Furthermore, we discuss representative electrochemical biosensing platforms which convert the biochemical reactions of those biomolecules into electrical signals (e.g., voltage, ampere, potential difference, impedance) to contribute to detect targets. This paper also highlights the successful outcomes of self-assembling biomolecules in biosensor applications and discusses the challenges that this promising technology needs to overcome for more widespread use. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-106967642023-12-06 Self-assembling biomolecules for biosensor applications Kim, Ji-eun Kang, Jeon Hyeong Kwon, Woo Hyun Lee, Inseo Park, Sang Jun Kim, Chun-Ho Jeong, Woo-jin Choi, Jun Shik Kim, Kyobum Biomater Res Review Molecular self-assembly has received considerable attention in biomedical fields as a simple and effective method for developing biomolecular nanostructures. Self-assembled nanostructures can exhibit high binding affinity and selectivity by displaying multiple ligands/receptors on their surface. In addition, the use of supramolecular structure change upon binding is an intriguing approach to generate binding signal. Therefore, many self-assembled nanostructure-based biosensors have been developed over the past decades, using various biomolecules (e.g., peptides, DNA, RNA, lipids) and their combinations with non-biological substances. In this review, we provide an overview of recent developments in the design and fabrication of self-assembling biomolecules for biosensing. Furthermore, we discuss representative electrochemical biosensing platforms which convert the biochemical reactions of those biomolecules into electrical signals (e.g., voltage, ampere, potential difference, impedance) to contribute to detect targets. This paper also highlights the successful outcomes of self-assembling biomolecules in biosensor applications and discusses the challenges that this promising technology needs to overcome for more widespread use. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2023-12-05 /pmc/articles/PMC10696764/ http://dx.doi.org/10.1186/s40824-023-00466-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kim, Ji-eun
Kang, Jeon Hyeong
Kwon, Woo Hyun
Lee, Inseo
Park, Sang Jun
Kim, Chun-Ho
Jeong, Woo-jin
Choi, Jun Shik
Kim, Kyobum
Self-assembling biomolecules for biosensor applications
title Self-assembling biomolecules for biosensor applications
title_full Self-assembling biomolecules for biosensor applications
title_fullStr Self-assembling biomolecules for biosensor applications
title_full_unstemmed Self-assembling biomolecules for biosensor applications
title_short Self-assembling biomolecules for biosensor applications
title_sort self-assembling biomolecules for biosensor applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696764/
http://dx.doi.org/10.1186/s40824-023-00466-8
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