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β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

BACKGROUND: Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoisobutyric...

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Detalles Bibliográficos
Autores principales:	Zhang, Ziyue, Li, Xingbing, Guo, Jingwen, He, Bo, Wu, Lianpan, Yang, Rongpei, Li, Xingyue, Fang, Dandong, Yang, XiaoLi, Yang, Donghai, Wang, Fengxian, Tang, Ming, Han, Yu, Jose, Pedro A., Wang, Hongyong, Zeng, Chunyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696792/ https://www.ncbi.nlm.nih.gov/pubmed/38049750 http://dx.doi.org/10.1186/s10020-023-00729-z

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