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Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning
Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening sequela of SARS-CoV-2 infection. Limited data are available regarding risk-stratification or long-term outcomes in MIS-C. This study sought to determine associations between serologic markers and severity of illness and unde...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696906/ https://www.ncbi.nlm.nih.gov/pubmed/37309831 http://dx.doi.org/10.1177/00099228231180411 |
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author | Alexander, Seth McKenzie Lykes, John Bryan Nassef, Christopher Whitham, Jennifer K. E. Ho, Jason G. Donell, Bridget B. |
author_facet | Alexander, Seth McKenzie Lykes, John Bryan Nassef, Christopher Whitham, Jennifer K. E. Ho, Jason G. Donell, Bridget B. |
author_sort | Alexander, Seth McKenzie |
collection | PubMed |
description | Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening sequela of SARS-CoV-2 infection. Limited data are available regarding risk-stratification or long-term outcomes in MIS-C. This study sought to determine associations between serologic markers and severity of illness and understand long-term cardiac outcomes. This series includes 46 cases (mean age 8.1 years; 63.0% male) of MIS-C. Pearson’s chi-squared analysis showed an erythrocyte sedimentation rate (ESR) greater than 30 mm/h and 50 mm/h were disproportionately associated with pediatric intensive care unit (PICU) admission (χ(2) = 4.44, P = .04) and use of vasopressors (χ(2) = 6.06, P = .01), respectively. Ferritin less than 175.6 ng/mL was associated with use of vasopressors (χ(2) = 5.28, P = .02). There was a negative correlation between ESR and ejection fraction (EF) (r = -0.39, P = .009). Most patients with abnormal echocardiograms had resolution of abnormalities within 30 days. Therefore, inflammatory markers may be helpful in predicting which patients may require specific interventions or experience cardiac dysfunction, but MIS-C does not appear to be associated with complications at 1 year. |
format | Online Article Text |
id | pubmed-10696906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-106969062023-12-06 Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning Alexander, Seth McKenzie Lykes, John Bryan Nassef, Christopher Whitham, Jennifer K. E. Ho, Jason G. Donell, Bridget B. Clin Pediatr (Phila) Articles Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening sequela of SARS-CoV-2 infection. Limited data are available regarding risk-stratification or long-term outcomes in MIS-C. This study sought to determine associations between serologic markers and severity of illness and understand long-term cardiac outcomes. This series includes 46 cases (mean age 8.1 years; 63.0% male) of MIS-C. Pearson’s chi-squared analysis showed an erythrocyte sedimentation rate (ESR) greater than 30 mm/h and 50 mm/h were disproportionately associated with pediatric intensive care unit (PICU) admission (χ(2) = 4.44, P = .04) and use of vasopressors (χ(2) = 6.06, P = .01), respectively. Ferritin less than 175.6 ng/mL was associated with use of vasopressors (χ(2) = 5.28, P = .02). There was a negative correlation between ESR and ejection fraction (EF) (r = -0.39, P = .009). Most patients with abnormal echocardiograms had resolution of abnormalities within 30 days. Therefore, inflammatory markers may be helpful in predicting which patients may require specific interventions or experience cardiac dysfunction, but MIS-C does not appear to be associated with complications at 1 year. SAGE Publications 2023-06-13 2024-01 /pmc/articles/PMC10696906/ /pubmed/37309831 http://dx.doi.org/10.1177/00099228231180411 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Articles Alexander, Seth McKenzie Lykes, John Bryan Nassef, Christopher Whitham, Jennifer K. E. Ho, Jason G. Donell, Bridget B. Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning |
title | Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning |
title_full | Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning |
title_fullStr | Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning |
title_full_unstemmed | Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning |
title_short | Multisystem Inflammatory Syndrome in Children: Two Years’ Worth of Learning |
title_sort | multisystem inflammatory syndrome in children: two years’ worth of learning |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696906/ https://www.ncbi.nlm.nih.gov/pubmed/37309831 http://dx.doi.org/10.1177/00099228231180411 |
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