Long-Term Opiate Therapy-Induced Secondary Adrenal Insufficiency: A Distinct Differential Diagnosis That Should Be Considered

Pain management with opioid medication is associated with several side effects. Opioid-induced adrenal insufficiency by suppression of the hypothalamic-pituitary-adrenal (HPA) axis is one of them that needs to be considered. The possible effects of opioid use on adrenal function are addressed in this case report. This is a case of a 21-year-old female patient with sickle cell disease who started, for the last year, on extended-release morphine sulfate 45mg daily in an attempt to control the severity of her pain and frequent admission with the vaso-occlusive crisis. She presented with a sepsis-like presentation and received vasopressor, empiric antibiotics, and glucocorticoid. She experienced low blood pressure and low blood glucose after weaning off of steroids. A diagnosis of secondary adrenal insufficiency was established after comprehensive reevaluation and confirmed by morning cortisol value and ACTH stimulation test. Her long-term use of opioids was considered the underlying cause of her secondary adrenal insufficiency after the exclusion of other causes and the normal pituitary gland on the brain magnetic resonance image. She received maintenance hydrocortisone. On follow-up, the patient showed effective improvement, and her adrenal function recovered after discontinuation of the morphine over the following six months. In conclusion, OIAI is an under-recognized condition of adrenal insufficiency secondary to long-term exposure to opioids. OIAI can cause symptoms and may result in potentially life-threatening adrenal crises, but it can be managed. A direct detrimental impact on the hypothalamus and pituitary gland mostly causes the suppression of cortisol secretion by opioids. Understanding how to diagnose and treat OIAI is crucial, particularly since opioids are widely used. To determine the frequency and clinical importance of opioid-induced adrenal insufficiency and if hormone replacement therapy is necessary, more research is required.