Cargando…
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
BACKGROUND: The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. However, based on reported human patient cases and studies with mouse models, it is hard to confirm the specific weight of haploinsufficiency in pathogenesis due to the...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696917/ https://www.ncbi.nlm.nih.gov/pubmed/38049871 http://dx.doi.org/10.1186/s13287-023-03590-3 |