Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using t...

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Detalles Bibliográficos
Autores principales: Hernández-Esparza, M. J., Fratoddi, Ilaria, Cerra, Sara, Juarez-Moreno, K., Huirache-Acuña, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696946/
http://dx.doi.org/10.1039/d3na00605k
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author Hernández-Esparza, M. J.
Fratoddi, Ilaria
Cerra, Sara
Juarez-Moreno, K.
Huirache-Acuña, R.
author_facet Hernández-Esparza, M. J.
Fratoddi, Ilaria
Cerra, Sara
Juarez-Moreno, K.
Huirache-Acuña, R.
author_sort Hernández-Esparza, M. J.
collection PubMed
description This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.
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spelling pubmed-106969462023-12-06 Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma Hernández-Esparza, M. J. Fratoddi, Ilaria Cerra, Sara Juarez-Moreno, K. Huirache-Acuña, R. Nanoscale Adv Chemistry This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology. RSC 2023-11-17 /pmc/articles/PMC10696946/ http://dx.doi.org/10.1039/d3na00605k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hernández-Esparza, M. J.
Fratoddi, Ilaria
Cerra, Sara
Juarez-Moreno, K.
Huirache-Acuña, R.
Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
title Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
title_full Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
title_fullStr Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
title_full_unstemmed Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
title_short Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma
title_sort hybrid aunps-3mps-mtx nanosystem and its evaluation for treating cervical cancer and melanoma
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10696946/
http://dx.doi.org/10.1039/d3na00605k
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